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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Igh-Jtm1(3H9-VDJ)Mwg
targeted mutation 1, Martin Weigert
MGI:3513167
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Igh-Jtm1(3H9-VDJ)Mwg/Igh-Jtm1(3H9-VDJ)Mwg involves: 129P2/OlaHsd * BALB/c * C57BL/6 MGI:3809008
cx2
 		Blnktm1Dkit/Blnktm1Dkit
Igh-Jtm1(3H9-VDJ)Mwg/Igh-J+ 		involves: C57BL/6 * NZB MGI:3513975
cx3
 		Blnktm1Dkit/Blnktm1Dkit
Igh-Jtm1(3H9-VDJ)Mwg/Igh-J+
Igk-Jtm1Mwg/Igk-J+ 		involves: C57BL/6 * NZB MGI:3513981


Genotype
MGI:3809008
hm1
Allelic
Composition		 Igh-Jtm1(3H9-VDJ)Mwg/Igh-Jtm1(3H9-VDJ)Mwg
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1(3H9-VDJ)Mwg mutation (4 available); any Igh-J mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell receptor editing ( J:126940 )
• the heavy chain encoded by the knocked-in allele is paired with a very limited repertoire of kappa light chains with the majority of these being from the Vkappa12/13 family
• these kappa light chains disrupt the DNA-binding ability of the heavy chain so that no B cells outside the bone marrow produce antibodies that bind double-stranded DNA

hematopoietic system
abnormal B cell receptor editing ( J:126940 )
• the heavy chain encoded by the knocked-in allele is paired with a very limited repertoire of kappa light chains with the majority of these being from the Vkappa12/13 family
• these kappa light chains disrupt the DNA-binding ability of the heavy chain so that no B cells outside the bone marrow produce antibodies that bind double-stranded DNA




Genotype
MGI:3513975
cx2
Allelic
Composition		 Blnktm1Dkit/Blnktm1Dkit
Igh-Jtm1(3H9-VDJ)Mwg/Igh-J+
Genetic
Background		 involves: C57BL/6 * NZB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blnktm1Dkit mutation (1 available); any Blnk mutation (78 available)
Igh-Jtm1(3H9-VDJ)Mwg mutation (4 available); any Igh-J mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal immature B cell morphology ( J:94297 )
• impaired editing of anti-DNA Ag receptors in splenic immature B cells

immune system
abnormal immature B cell morphology ( J:94297 )
• impaired editing of anti-DNA Ag receptors in splenic immature B cells




Genotype
MGI:3513981
cx3
Allelic
Composition		 Blnktm1Dkit/Blnktm1Dkit
Igh-Jtm1(3H9-VDJ)Mwg/Igh-J+
Igk-Jtm1Mwg/Igk-J+
Genetic
Background		 involves: C57BL/6 * NZB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blnktm1Dkit mutation (1 available); any Blnk mutation (78 available)
Igh-Jtm1(3H9-VDJ)Mwg mutation (4 available); any Igh-J mutation (13 available)
Igk-Jtm1Mwg mutation (1 available); any Igk-J mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal immature B cell morphology ( J:94297 )
• decreased number of B cells in bone marrow and spleen
• receptor editing of dsDNA binding BCR replacing kappa chain with lamda was hampered resulting in suppression of lambda + B cells to 5% (compared to 22% in cells with wild-type Blnk)

immune system
abnormal immature B cell morphology ( J:94297 )
• decreased number of B cells in bone marrow and spleen
• receptor editing of dsDNA binding BCR replacing kappa chain with lamda was hampered resulting in suppression of lambda + B cells to 5% (compared to 22% in cells with wild-type Blnk)




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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory