Phenotypes associated with this allele

• Allele Symbol: Prl8a2^tm1Soar
• Allele Name: targeted mutation 1, Michael J Soares
• Allele ID: MGI:3513194
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prl8a2^tm1Soar/Prl8a2^tm1Soar	either: B6.129-Prl8a2^tm1Soar or 129X1.129-Prl8a2^tm1Soar	MGI:3717766

Genotype
MGI:3717766

hm1

• Allelic Composition: Prl8a2^tm1Soar/Prl8a2^tm1Soar
• Genetic Background: either: B6.129-Prl8a2^tm1Soar or 129X1.129-Prl8a2^tm1Soar

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal response to injury ( J:117034 )

• exposing pregnant females to hypoxic conditions on E5.5 and E6.5 results in death or resorption of most fetal-placental units at E17.5 whereas wild-type mice are unaffected

• following exposure to hypoxic conditions, the chorioallantoic placental organization is enlarged and distorted at E11.5

• following exposure to hypoxic conditions, hemorrhages are observed in uteroplacental compartments at E11.5

• following exposure to hypoxic conditions, trophoblast giant cells are overgrown at E11.5

• following exposure to hypoxic conditions, there is a decrease in the invasion of endovascular cells at E11.5

• following exposure to hypoxic conditions, mesometrial compartments have enlarged blood spaces and the mesometrial deciduas is compressed

reproductive system

abnormal decidualization ( J:117034 )

♀ • following exposure to hypoxic conditions, the mesometrial deciduas is compressed

abnormal ovary morphology ( J:117034 )

♀ • following exposure to hypoxic conditions, mesometrial compartments have enlarged blood spaces and the mesometrial deciduas is compressed

embryo

abnormal trophoblast layer morphology ( J:117034 )

• following exposure to hypoxic conditions, there is a increase in the invasion of endovascular cells at E11.5

abnormal trophoblast giant cell morphology ( J:117034 )

• following exposure to hypoxic conditions, trophoblast giant cells are overgrown at E11.5

abnormal placenta development ( J:117034 )

• following exposure to hypoxic conditions, the chorioallantoic placental organization is enlarged and distorted at E11.5

• following exposure to hypoxic conditions, hemorrhages are observed in uteroplacental compartments at E11.5

abnormal decidualization ( J:117034 )

♀ • following exposure to hypoxic conditions, the mesometrial deciduas is compressed

cardiovascular system

hemorrhage ( J:117034 )

• following exposure to hypoxic conditions, hemorrhages are observed in uteroplacental compartments at E11.5

endocrine/exocrine glands

abnormal ovary morphology ( J:117034 )

♀ • following exposure to hypoxic conditions, mesometrial compartments have enlarged blood spaces and the mesometrial deciduas is compressed