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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Igk-Jtm1Mwg
targeted mutation 1, Martin Weigert
MGI:3513200
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Igk-Jtm1Mwg/Igktm1Dhu involves: 129S7/SvEvBrd * C57BL/6 MGI:3717905
cx2
 		Blnktm1Dkit/Blnktm1Dkit
Igh-Jtm1(3H9-VDJ)Mwg/Igh-J+
Igk-Jtm1Mwg/Igk-J+ 		involves: C57BL/6 * NZB MGI:3513981


Genotype
MGI:3717905
cx1
Allelic
Composition		 Igk-Jtm1Mwg/Igktm1Dhu
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igk-Jtm1Mwg mutation (1 available); any Igk-J mutation (11 available)
Igktm1Dhu mutation (1 available); any Igk mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:76116 )
N
• IgM density at the pre-B and immature B cell stages is indistinguishable from wild-type mice




Genotype
MGI:3513981
cx2
Allelic
Composition		 Blnktm1Dkit/Blnktm1Dkit
Igh-Jtm1(3H9-VDJ)Mwg/Igh-J+
Igk-Jtm1Mwg/Igk-J+
Genetic
Background		 involves: C57BL/6 * NZB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blnktm1Dkit mutation (1 available); any Blnk mutation (78 available)
Igh-Jtm1(3H9-VDJ)Mwg mutation (4 available); any Igh-J mutation (13 available)
Igk-Jtm1Mwg mutation (1 available); any Igk-J mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal immature B cell morphology ( J:94297 )
• decreased number of B cells in bone marrow and spleen
• receptor editing of dsDNA binding BCR replacing kappa chain with lamda was hampered resulting in suppression of lambda + B cells to 5% (compared to 22% in cells with wild-type Blnk)

immune system
abnormal immature B cell morphology ( J:94297 )
• decreased number of B cells in bone marrow and spleen
• receptor editing of dsDNA binding BCR replacing kappa chain with lamda was hampered resulting in suppression of lambda + B cells to 5% (compared to 22% in cells with wild-type Blnk)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory