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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lmo4tm1Slp
targeted mutation 1, Samuel L Pfaff
MGI:3513311
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Lmo4tm1Slp/Lmo4tm1Slp
Commd10Tg(Vav1-icre)A2Kio/Commd10+ 		involves: 129S1/Sv * C57BL/6 * C57BL/10 * CBA/Ca MGI:6385528
cn2
 		Lmo4tm1Slp/Lmo4tm1Slp
Yeats4em1Zfa/Yeats4em1Zfa
Commd10Tg(Vav1-icre)A2Kio/Commd10+ 		involves: 129S1/Sv * C57BL/6 * C57BL/10 * CBA/Ca MGI:6385529


Genotype
MGI:6385528
cn1
Allelic
Composition		 Lmo4tm1Slp/Lmo4tm1Slp
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (3 available); any Commd10 mutation (24 available)
Lmo4tm1Slp mutation (0 available); any Lmo4 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal lymphopoiesis ( J:282740 )
• frequencies of alpha-lymphoid progenitors, common helper innate lymphoid cell progenitors (CHILPs), and innate lymphoid cell precursors (ILCPs) are reduced in the small intestine and liver, ILC2s in the small intestine and lung, and ILC3s in the small intestine
• mutant common lymphoid progenitors (CLPs) engrafted into Rag1/Il2rg null recipients produce fewer numbers of innate lymphoid cells (ILCs)
• differentiation ability of alpha4Beta7+ CLPs in culture is suppressed
• however, normal frequencies of alpha4Beta7+ CLPs are seen
abnormal lymphocyte physiology ( J:282740 )
• mice exhibit a reduced number of IFN-gamma+ group 1 innate lymphoid cells (ILC1s) after S. typhimurium infection
• mice show a decreased number of group 2 innate lymphoid cells (ILC2s) in the lung and a reduced number of IL-5 and IL-13 secreting ILC2s in the lung after papain challenge

immune system
abnormal lymphopoiesis ( J:282740 )
• frequencies of alpha-lymphoid progenitors, common helper innate lymphoid cell progenitors (CHILPs), and innate lymphoid cell precursors (ILCPs) are reduced in the small intestine and liver, ILC2s in the small intestine and lung, and ILC3s in the small intestine
• mutant common lymphoid progenitors (CLPs) engrafted into Rag1/Il2rg null recipients produce fewer numbers of innate lymphoid cells (ILCs)
• differentiation ability of alpha4Beta7+ CLPs in culture is suppressed
• however, normal frequencies of alpha4Beta7+ CLPs are seen
abnormal lymphocyte physiology ( J:282740 )
• mice exhibit a reduced number of IFN-gamma+ group 1 innate lymphoid cells (ILC1s) after S. typhimurium infection
• mice show a decreased number of group 2 innate lymphoid cells (ILC2s) in the lung and a reduced number of IL-5 and IL-13 secreting ILC2s in the lung after papain challenge
abnormal gut-associated lymphoid tissue morphology ( J:282740 )
• number of intestinal lymphoid follicles is decreased
• however, NK cells in the spleen and blood are not affected
decreased Peyer's patch number ( J:282740 )
• number of Peyers patches is decreased
abnormal acute inflammation ( J:282740 )
• leukocyte infiltration is attenuated in the lungs after papain challenge
increased susceptibility to bacterial infection ( J:282740 )
• mice exhibit a higher number of S. typhimurium CFUs in mesenteric lymph nodes after infection than controls
• mice exhibit a higher number of bacterial CFUs in feces, weight loss and shrinking colon length accompanied by more severe intestinal damage after C. rodentium infection




Genotype
MGI:6385529
cn2
Allelic
Composition		 Lmo4tm1Slp/Lmo4tm1Slp
Yeats4em1Zfa/Yeats4em1Zfa
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (3 available); any Commd10 mutation (24 available)
Lmo4tm1Slp mutation (0 available); any Lmo4 mutation (9 available)
Yeats4em1Zfa mutation (0 available); any Yeats4 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal lymphopoiesis ( J:282740 )
• mutant alpha4Beta7+ common lymphoid progenitors (CLPs) engrafted into Rag1/Il2rg null recipients produce fewer numbers of innate lymphoid cells (ILCs)
• differentiation ability of alpha4Beta7+ CLPs in culture is impaired
abnormal lymphocyte physiology ( J:282740 )
• mice exhibit a reduced number of IFN-gamma+ group 1 innate lymphoid cells (ILC1s) after S. typhimurium infection
• mice show a decreased number of group 2 innate lymphoid cells (ILC2s) in the lung and a reduced number of IL-5 and IL-13 secreting ILC2s in the lung after papain challenge

immune system
abnormal lymphopoiesis ( J:282740 )
• mutant alpha4Beta7+ common lymphoid progenitors (CLPs) engrafted into Rag1/Il2rg null recipients produce fewer numbers of innate lymphoid cells (ILCs)
• differentiation ability of alpha4Beta7+ CLPs in culture is impaired
abnormal lymphocyte physiology ( J:282740 )
• mice exhibit a reduced number of IFN-gamma+ group 1 innate lymphoid cells (ILC1s) after S. typhimurium infection
• mice show a decreased number of group 2 innate lymphoid cells (ILC2s) in the lung and a reduced number of IL-5 and IL-13 secreting ILC2s in the lung after papain challenge
abnormal acute inflammation ( J:282740 )
• leukocyte infiltration is attenuated in the lungs after papain challenge
increased susceptibility to bacterial infection ( J:282740 )
• mice exhibit a higher number of S. typhimurium CFUs in mesenteric lymph nodes after infection than controls
• mice exhibit a higher number of bacterial CFUs in feces, weight loss and shrinking colon length accompanied by more severe intestinal damage after C. rodentium infection




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory