Phenotypes associated with this allele

• Allele Symbol: Grxcr1^{pi-Tg(Eno2-Gabrb3)0370Brll}
• Allele Name: transgene insertion 0370, Murray H Brilliant
• Allele ID: MGI:3513407
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grxcr1^pi-Tg(Eno2-Gabrb3)0370Brll/Grxcr1^pi-Tg(Eno2-Gabrb3)0370Brll	involves: C3H * C57BL/6J	MGI:3718025

Genotype
MGI:3718025

hm1

• Allelic Composition: Grxcr1^{pi-Tg(Eno2-Gabrb3)0370Brll}/Grxcr1^{pi-Tg(Eno2-Gabrb3)0370Brll}
• Genetic Background: involves: C3H * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

absent startle reflex ( J:93174 )

• failed to exhibit a startle reflex in response to loud noise

head bobbing ( J:93174 )

• distinctive head shaking by P7

bidirectional circling ( J:93174 )

• by P7

hearing/vestibular/ear

abnormal outer hair cell stereociliary bundle morphology ( J:93174 )

• lack of a consistent staircase arrangement of stereocilia on outer hair cells with numerous ectopic microvilli

• exhibited numerous extensions that were significantly longer than normal stereocilia

abnormal cochlear inner hair cell morphology ( J:93174 )

• the presence of actin-rich structures, known as cytocauds

abnormal inner hair cell stereociliary bundle morphology ( J:93174 )

• at the apical surface of sensory hair cells, qualitatively thin and disorganized stereocilia on inner hair cells

• exhibited numerous extensions that were significantly longer than normal stereocilia

abnormal type I vestibular cell ( J:93174 )

• the presence of actin-rich structures, known as cytocauds

increased or absent threshold for auditory brainstem response ( J:93174 )

• no response to tones at any frequency in 10 weeks old mutant mice at even the highest intensity levels

deafness ( J:93174 )

nervous system

abnormal outer hair cell stereociliary bundle morphology ( J:93174 )

• lack of a consistent staircase arrangement of stereocilia on outer hair cells with numerous ectopic microvilli

• exhibited numerous extensions that were significantly longer than normal stereocilia

abnormal cochlear inner hair cell morphology ( J:93174 )

• the presence of actin-rich structures, known as cytocauds

abnormal inner hair cell stereociliary bundle morphology ( J:93174 )

• at the apical surface of sensory hair cells, qualitatively thin and disorganized stereocilia on inner hair cells

• exhibited numerous extensions that were significantly longer than normal stereocilia

abnormal type I vestibular cell ( J:93174 )

• the presence of actin-rich structures, known as cytocauds