Phenotypes associated with this allele

• Allele Symbol: Apc^tm1Cip
• Allele Name: targeted mutation 1, Christine Perret
• Allele ID: MGI:3513416
• Summary: 7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Apc^tm1Cip/Apc^tm1Cip	involves: 129P2/OlaHsd * C57BL/6	MGI:3513847
ht2	Apc^tm1Cip/Apc^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3513849
cx3	Apc^tm1Cip/Apc^+ H19^tm1Lda/H19^+	involves: 129P2/OlaHsd * 129S2/SvPas	MGI:3845818
cx4	Apc^tm1Cip/Apc^+ H19^tm1Lda/H19^+	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA	MGI:3845817
cx5	Apc^tm1Cip/Apc^+ Cdhr5^tm1Lex/Cdhr5^tm1Lex	involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6	MGI:6713511
cx6	Apc^tm1Cip/Apc^+ Mki67^em1Dfis/Mki67^em1Dfis	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J	MGI:6715308
cx7	Apc^tm1Cip/Apc^+ Nrip1^tm1Mpk/Nrip1^+	involves: 129P2/OlaHsd * C57BL/6J	MGI:5574446

Genotype
MGI:3513847

hm1

• Allelic Composition: Apc^tm1Cip/Apc^tm1Cip
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:94108 )

• no newborn homozygous pups are seen

Genotype
MGI:3513849

ht2

• Allelic Composition: Apc^tm1Cip/Apc⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

premature death ( J:94108 )

• heterozygotes begin to die at 4 months of age with 50% dying by 6 months of age

neoplasm

increased intestinal adenocarcinoma incidence ( J:94108 )

• in situ carcinomas are seen in both the small and large intestines

• over 50% of lesions in mutants over 12 months of age are tubular adenomas harboring invasive carcinomas

increased intestinal adenoma incidence ( J:94108 )

• small and large adenomas are seen throughout the intestine

• the number of polyps is increased and the distribution of polyps shifted towards the ileum under specific pathogen-free conditions

increased colon adenoma incidence ( J:94108 )

• compared to Apc^Min heterozygotes more lesions are see in the colon, however the overall number of lesions is the same in both lines

increased mammary adenocarcinoma incidence ( J:94108 )

• 9% of heterozygotes developed mammary adenocanthomas

cardiovascular system

rectal hemorrhage ( J:94108 )

• first seen around 4 months of age, associated with decreased life span

digestive/alimentary system

rectal hemorrhage ( J:94108 )

• first seen around 4 months of age, associated with decreased life span

rectal prolapse ( J:94108 )

• the prolapse is highly dysplatic and in 10% of these dysplatic areas adenocarcinoma is also seen

• rectal prolapse, associated with more severe polyposis in the colon, is seen as early as 4 months of age and is seen in 61% of surviving mutants by 6 months of age

• fewer mutants raised in specific pathogen-free conditions developed rectal prolapse

increased intestinal adenocarcinoma incidence ( J:94108 )

• in situ carcinomas are seen in both the small and large intestines

• over 50% of lesions in mutants over 12 months of age are tubular adenomas harboring invasive carcinomas

increased intestinal adenoma incidence ( J:94108 )

• small and large adenomas are seen throughout the intestine

• the number of polyps is increased and the distribution of polyps shifted towards the ileum under specific pathogen-free conditions

increased colon adenoma incidence ( J:94108 )

• compared to Apc^Min heterozygotes more lesions are see in the colon, however the overall number of lesions is the same in both lines

hematopoietic system

anemia ( J:94108 )

• first seen around 4 months of age, associated with decreased life span

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:94108 )

• 9% of heterozygotes developed mammary adenocanthomas

integument

increased mammary adenocarcinoma incidence ( J:94108 )

• 9% of heterozygotes developed mammary adenocanthomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
colorectal cancer		DOID:9256	OMIM:114500	J:94108
familial adenomatous polyposis		DOID:0050424	OMIM:PS175100	J:94108

Genotype
MGI:3845818

cx3

• Allelic Composition: Apc^tm1Cip/Apc⁺; H19^tm1Lda/H19⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

neoplasm

increased adenoma incidence ( J:138826 )

• mice exhibit a 1.4-fold increase in the number of adenomas compared to in Apc^tm1Cip heterozygotes

Genotype
MGI:3845817

cx4

• Allelic Composition: Apc^tm1Cip/Apc⁺; H19^tm1Lda/H19⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA

neoplasm

increased intestinal adenocarcinoma incidence ( J:138826 )

• some adenocarcinoma in situ in the intestines

increased adenoma incidence ( J:138826 )

• mice exhibit a 2.2-fold increase in the number of adenomas compared to in Apc^tm1Cip heterozygotes

digestive/alimentary system

colon polyps ( J:138826 )

• mice exhibit a 3-fold increase in the number of small polyps compared to in Apc^tm1Cip heterozygotes

increased intestinal adenocarcinoma incidence ( J:138826 )

• some adenocarcinoma in situ in the intestines

Genotype
MGI:6713511

cx5

• Allelic Composition: Apc^tm1Cip/Apc⁺; Cdhr5^tm1Lex/Cdhr5^tm1Lex
• Genetic Background: involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6

digestive/alimentary system

increased intestinal adenoma incidence ( J:301471 )

• at 6-8 months of age, 83% of mice show symptoms of neoplasia (rectal bleeding, anemia, splenomegaly) and 1 or more macroadenomas in the intestinal tract relative to 56% in Apc^tm1Cip heterozygotes

• a greater % of mice develop 51 to 100 or over 100 polyps (all sizes) in the intestinal tract, and the average number of tumors per mouse is ~3-fold higher than that in Apc^tm1Cip heterozygotes

neoplasm

increased intestinal adenoma incidence ( J:301471 )

• at 6-8 months of age, 83% of mice show symptoms of neoplasia (rectal bleeding, anemia, splenomegaly) and 1 or more macroadenomas in the intestinal tract relative to 56% in Apc^tm1Cip heterozygotes

• a greater % of mice develop 51 to 100 or over 100 polyps (all sizes) in the intestinal tract, and the average number of tumors per mouse is ~3-fold higher than that in Apc^tm1Cip heterozygotes

increased tumor growth/size ( J:301471 )

• mice develop more tumors, esp. larger ones, in the intestinal tract; the average number of macroadenomas (>5 mm) per mouse is ~3-fold higher than that in Apc^tm1Cip heterozygotes

• however, no differences in tumor grade, aggressiveness or proliferation are observed

Genotype
MGI:6715308

cx6

• Allelic Composition: Apc^tm1Cip/Apc⁺; Mki67^em1Dfis/Mki67^em1Dfis
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

neoplasm

decreased incidence of tumors by chemical induction ( J:304800 )

• 6 months after induction of colon tumors by AOM-DSS treatment, mice exhibit a significant decrease both in the number of neoplastic lesions/mouse and in total lesion area (mm2) relative to similarly treated mice heterozygous for Mki67^em1Dfis and Apc^tm1Cip

decreased tumor growth/size ( J:304800 )

• 6 months after AOM-DSS treatment, mice exhibit a significant decrease in total lesion area (mm2) relative to similarly treated mice heterozygous for Mki67^em1Dfis and Apc^tm1Cip

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:304800 )

• 6 months after induction of colon tumors by AOM-DSS treatment, mice exhibit a significant decrease both in the number of neoplastic lesions/mouse and in total lesion area (mm2) relative to similarly treated mice heterozygous for Mki67^em1Dfis and Apc^tm1Cip

Genotype
MGI:5574446

cx7

• Allelic Composition: Apc^tm1Cip/Apc⁺; Nrip1^tm1Mpk/Nrip1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

mortality/aging

premature death ( J:211324 )

♀ • compared with Apc^tm1Cip heterozygotes