cellular
|
• disappearance of the double structure of mitochondrial membranes in the liver
|
liver/biliary system
• mild steatosis at young age that becomes moderate to severe with increasing age
(J:94426)
• all males and about 50% of females develop steatosis by 6 months of age
(J:94426)
• however, mice show normal weight and total cholesterol and triglyceride levels
(J:94426)
|
|
|
(J:52686)
|
|
• hepatocellular carcinoma develops from within the adenomas without cytoplasmic fat droplets
|
|
• 25.9% of male mice develop hepatic tumors after 16 months of age that first appear as adenomas containing fat droplets in the cytoplasm
|
neoplasm
|
• hepatocellular carcinoma develops from within the adenomas without cytoplasmic fat droplets
|
|
• 25.9% of male mice develop hepatic tumors after 16 months of age that first appear as adenomas containing fat droplets in the cytoplasm
|