Phenotypes associated with this allele

• Allele Symbol: Tg(HBV-HCV)49Kko
• Allele Name: transgene insertion 49, Kazuhiko Koike
• Allele ID: MGI:3513426
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(HBV-HCV)49Kko/0	C57BL/6N-Tg(HBV-HCV)49Kko	MGI:5578175

Genotype
MGI:5578175

tg1

• Allelic Composition: Tg(HBV-HCV)49Kko/0
• Genetic Background: C57BL/6N-Tg(HBV-HCV)49Kko

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal mitochondrial inner membrane morphology ( J:52686 )

♂ • disappearance of the double structure of mitochondrial membranes in the liver

liver/biliary system

hepatic steatosis ( J:52686 , J:94426 )

♂ • mild steatosis at young age that becomes moderate to severe with increasing age (J:52686)

♂ • all males and about 50% of females develop steatosis by 6 months of age (J:52686)

♂ • however, mice show normal weight and total cholesterol and triglyceride levels (J:52686)

increased hepatocellular carcinoma incidence ( J:52686 )

♂ • hepatocellular carcinoma develops from within the adenomas without cytoplasmic fat droplets

increased liver adenoma incidence ( J:52686 )

♂ • 30.8% of male mice develop hepatic tumors after 16 months of age that first appear as adenomas containing fat droplets in the cytoplasm

neoplasm

increased hepatocellular carcinoma incidence ( J:52686 )

♂ • hepatocellular carcinoma develops from within the adenomas without cytoplasmic fat droplets

increased liver adenoma incidence ( J:52686 )

♂ • 30.8% of male mice develop hepatic tumors after 16 months of age that first appear as adenomas containing fat droplets in the cytoplasm