Phenotypes associated with this allele

• Allele Symbol: chohr3
• Allele Name: recessive hypercholesterolemia 3
• Allele ID: MGI:3513445
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	chohr3/chohr3	C3HeB/FeJ-chohr3/Ieg	MGI:3513917

Genotype
MGI:3513917

hm1

• Allelic Composition: chohr3/chohr3
• Genetic Background: C3HeB/FeJ-chohr3/Ieg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:94145 )

• mutants die around 5 months of age

hematopoietic system

microcytic anemia ( J:94145 )

homeostasis/metabolism

increased circulating creatinine level ( J:94145 )

• plasma creatinine levels are increased

increased blood urea nitrogen level ( J:94145 )

increased circulating cholesterol level ( J:94145 )

• mean serum cholesterol is 212 mg/ml and 202 mg/ml for male and female mutants, respectively, with 100% penetrance

increased circulating HDL cholesterol level ( J:94145 )

• mean serum HDL cholesterol is 24 mg/ml and 35 mg/ml for male and female mutants, respectively

increased circulating LDL cholesterol level ( J:94145 )

• mean serum LDL cholesterol is 167 mg/ml and 152 mg/ml for male and female mutants, respectively

abnormal urine homeostasis ( J:94145 )

• urea and creatinine levels in urine are decreased

albuminuria ( J:94145 )

renal/urinary system

abnormal urine homeostasis ( J:94145 )

• urea and creatinine levels in urine are decreased

albuminuria ( J:94145 )