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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lalbatm1Jvt
targeted mutation 1, J L Vilotte
MGI:3513842
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lalbatm1Jvt/Lalbatm1Jvt involves: 129S2/SvPas * C57BL/6 MGI:3513979
ht2
 		Lalbatm1Jvt/Lalba+ involves: 129S2/SvPas * C57BL/6 MGI:3513982


Genotype
MGI:3513979
hm1
Allelic
Composition		 Lalbatm1Jvt/Lalbatm1Jvt
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lalbatm1Jvt mutation (0 available); any Lalba mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal mammary gland morphology ( J:19377 )
• the volume of the cytoplasm, secretory vesicles and Golgi apparatus are reduced in epithelial cells and fat globules that are normally confined within the cell invade the extra-cellular space
abnormal milk composition ( J:19377 )
• milk is 10 times as viscous as milk from heterozygotes, has increased solid content and fat and protein levels, and lacks lactose and derived sugars
• females are unable to feed their offspring

integument
abnormal mammary gland morphology ( J:19377 )
• the volume of the cytoplasm, secretory vesicles and Golgi apparatus are reduced in epithelial cells and fat globules that are normally confined within the cell invade the extra-cellular space
abnormal milk composition ( J:19377 )
• milk is 10 times as viscous as milk from heterozygotes, has increased solid content and fat and protein levels, and lacks lactose and derived sugars
• females are unable to feed their offspring




Genotype
MGI:3513982
ht2
Allelic
Composition		 Lalbatm1Jvt/Lalba+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lalbatm1Jvt mutation (0 available); any Lalba mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal mammary gland morphology ( J:19377 )
• fat globules that are normally confined within the cell invade the extra-cellular space
abnormal milk composition ( J:19377 )
• milk is 3 times as viscous as milk from wild-type mice, has increased solid content and fat and protein levels, and 10% less lactose, however females can still feed their offspring

integument
abnormal mammary gland morphology ( J:19377 )
• fat globules that are normally confined within the cell invade the extra-cellular space
abnormal milk composition ( J:19377 )
• milk is 3 times as viscous as milk from wild-type mice, has increased solid content and fat and protein levels, and 10% less lactose, however females can still feed their offspring




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory