Phenotypes associated with this allele

• Allele Symbol: Htr5a^tm1Rhn
• Allele Name: targeted mutation 1, Rene Hen
• Allele ID: MGI:3513844
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Htr5a^tm1Rhn/Htr5a^tm1Rhn	involves: 129S2/SvPas	MGI:3513992

Genotype
MGI:3513992

hm1

• Allelic Composition: Htr5a^tm1Rhn/Htr5a^tm1Rhn
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal response to novelty ( J:54098 )

• homozygotes spend more time investigating a novel object

• LSD still induces an initial decrease in exploratory behavior but the later increase is largely attenuated in mutants unlike in wild-type mice

increased exploration in new environment ( J:54098 )

• homozygotes are more active in a novel environment however basal activity and anxiety behaviors are not different from wild-type