Phenotypes associated with this allele

• Allele Symbol: Rtn4r^tm1Stmr
• Allele Name: targeted mutation 1, Stephen M Strittmatter
• Allele ID: MGI:3514018
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rtn4r^tm1Stmr/Rtn4r^tm1Stmr	involves: 129X1/SvJ * C57BL/6J	MGI:3514292
cx2	Crtac1^tm1Kota/Crtac1^tm1Kota Rtn4r^tm1Stmr/Rtn4r^tm1Stmr	involves: 129X1/SvJ * C57BL/6	MGI:5141318

Genotype
MGI:3514292

hm1

• Allelic Composition: Rtn4r^tm1Stmr/Rtn4r^tm1Stmr
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased exploration in new environment ( J:94754 )

• homozygotes spend more time in the marginal zone of the open field and make fewer movements, however their Basso-Beattie-Bresnahan score (a measure of locomotor function) is normal

impaired coordination ( J:94754 )

• mutants perform worse on the rotarod compared to wild-type and heterozygous littermates

nervous system

enhanced central nervous system regeneration ( J:94754 )

• mutants show improved recovery after spinal cord injury involving midthoracic dorsal hemisection injury or complete transection at thoracic level 8 as measured by improved locomotor activity and restored transcranial magnetic motor-evoked potentials

• rubrospinal axons and raphespinal fibers regenerate following transection injury and can be detected crossing the lesion site

Genotype
MGI:5141318

cx2

• Allelic Composition: Crtac1^tm1Kota/Crtac1^tm1Kota; Rtn4r^tm1Stmr/Rtn4r^tm1Stmr
• Genetic Background: involves: 129X1/SvJ * C57BL/6

nervous system

abnormal olfactory tract morphology ( J:174418 )

• relative width of the lateral olfactory tract is reduced compared to mice homozygous for Crtac1^tm1Gosh