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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nde1tm1Caw
targeted mutation 1, Christopher A Walsh
MGI:3514026
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nde1tm1Caw/Nde1tm1Caw involves: 129S4/SvJae * Black Swiss MGI:3514153
cx2
Nde1tm1Caw/Nde1tm1Caw
Pafah1b1tm1Awb/Pafah1b1+
involves: 129S4/SvJae * 129S6/SvEvTac MGI:5515910


Genotype
MGI:3514153
hm1
Allelic
Composition
Nde1tm1Caw/Nde1tm1Caw
Genetic
Background
involves: 129S4/SvJae * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nde1tm1Caw mutation (1 available); any Nde1 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• progressive decrease in cortical progenitor cell proliferation
• altered neuronal cell fate with more neural progenitor cells adapting a neuronal fate between E14.5-E15.5, leading to an increase in deeper layer neurons
• 1.8 fold increase in mitotic cells in the cortical ventricular zone at E15
• altered mitotic orientation (reduction in symmetrical cell division and increase in asymmetrical cell division) and mispositioned mitotic chromosomes in neural progenitor cells
• cerebral cortex neurons at E15 and E17 showed a reduced distance of migration and a more scattered distribution
• brain was 1/3 smaller at 6-8 weeks of age with small size observed from birth throughout adult life
• the weight of the anterior forebrain was reduced much more than the posterior midbrain and cerebellum
• thinner cerebral cortex showing a pronounced thinning in the superficial cortical layers
• severe reduction in later-born superficial cortical neurons (neurons in layers II/III to IV)

cellular
• progressive decrease in cortical progenitor cell proliferation
• altered neuronal cell fate with more neural progenitor cells adapting a neuronal fate between E14.5-E15.5, leading to an increase in deeper layer neurons
• 1.8 fold increase in mitotic cells in the cortical ventricular zone at E15
• altered mitotic orientation (reduction in symmetrical cell division and increase in asymmetrical cell division) and mispositioned mitotic chromosomes in neural progenitor cells
• cerebral cortex neurons at E15 and E17 showed a reduced distance of migration and a more scattered distribution




Genotype
MGI:5515910
cx2
Allelic
Composition
Nde1tm1Caw/Nde1tm1Caw
Pafah1b1tm1Awb/Pafah1b1+
Genetic
Background
involves: 129S4/SvJae * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nde1tm1Caw mutation (1 available); any Nde1 mutation (32 available)
Pafah1b1tm1Awb mutation (0 available); any Pafah1b1 mutation (160 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• normal size and shape of dorsal root ganglia
• expanded roof plate
• cells continue to divide through E13
• massive expansion of choroid plexus epithelium cells
• profound loss of neocortical neurons
• extensive loss of neurons in the dorsal spinal cord
• large number of dorsal sensory interneurons are missing
• near complete loss of dorsal sensory interneurons with only modest losses in the ventral spinal cord
• dorsal progenitors are greatly reduced distal to the roof plate
• ventral spinal cord patterning and dorsal most domain of the ventral spinal cord are only modestly affected

embryo
• expanded roof plate
• cells continue to divide through E13





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory