Analysis Tools
adipose tissue
|
• less periorgan adipose tissue
|
homeostasis/metabolism
|
• phenotype was reversed when rodent chow was fortified with ezetimibe, a drug that blocks dietary sterol absorption by >90%
|
|
• 8-fold increase of plasma campesterol relative to controls
• 36-fold increase of plasma sitosterol relative to controls
|
|
• higher triglyceride levels in fasted mutants fed a regular diet
|
|
• decrease in plasma, liver, and spleen cholesterol levels
|
|
• 52% decrease in plasma cholesterol levels
|
reproductive system
 |
• phenotype was reversed when rodent chow was fortified with ezetimibe, a drug that blocks dietary sterol absorption by >90%
|
 |
• phenotype was reversed when rodent chow was fortified with ezetimibe, a drug that blocks dietary sterol absorption by >90%
|
liver/biliary system
|
• 50% decrease in liver cholesterol content
• 5-fold and 22-fold increase in liver campesterol and sitosterol content, respectively
• reduced biliary sterol and phospholipid content
• under conditions that force biliary sterol secretion, cholesterol secretion into bile was diminished but sitosterol and campesterol secretion was maintained
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| sitosterolemia 1 | DOID:0090019 |
OMIM:210250 |
J:94759 | |
