Phenotypes associated with this allele

• Allele Symbol: Mtap^{Gt(RRK081)Byg}
• Allele Name: gene trap RRK081, BayGenomics
• Allele ID: MGI:3514132
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mtap^Gt(RRK081)Byg/Mtap^Gt(RRK081)Byg	129P2/OlaHsd-Mtap^Gt(RRK081)Byg	MGI:3719680
ht2	Mtap^Gt(RRK081)Byg/Mtap^+	129P2/OlaHsd-Mtap^Gt(RRK081)Byg	MGI:3719682
ht3	Mtap^Gt(RRK081)Byg/Mtap^+	involves: 129P2/OlaHsd * CBA/CaJ	MGI:3719687

Genotype
MGI:3719680

hm1

• Allelic Composition: Mtap^{Gt(RRK081)Byg}/Mtap^{Gt(RRK081)Byg}
• Genetic Background: 129P2/OlaHsd-Mtap^{Gt(RRK081)Byg}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:123675 )

• homozygotes die by E8.5

Genotype
MGI:3719682

ht2

• Allelic Composition: Mtap^{Gt(RRK081)Byg}/Mtap⁺
• Genetic Background: 129P2/OlaHsd-Mtap^{Gt(RRK081)Byg}

cardiovascular system

arteritis ( J:123675 )

• at 4 to 7 months of age, some heterozygotes display polyarteritis nodosa; however, no consistent phenotype is observed

liver/biliary system

abnormal liver morphology ( J:123675 )

• at 4 to 7 months of age, some heterozygotes display unusual vacuoles in the liver; however, no consistent phenotype is observed

respiratory system

abnormal bronchus morphology ( J:123675 )

• at 4 to 7 months of age, some heterozygotes display dilated bronchi; however, no consistent phenotype is observed

immune system

arteritis ( J:123675 )

• at 4 to 7 months of age, some heterozygotes display polyarteritis nodosa; however, no consistent phenotype is observed

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:123675 )

N • at 5 and a half weeks of age, heterozygotes display normal cochlear function, with no significant differences in ABR and DPOAE thresholds relative to wild-type mice

Genotype
MGI:3719687

ht3

• Allelic Composition: Mtap^{Gt(RRK081)Byg}/Mtap⁺
• Genetic Background: involves: 129P2/OlaHsd * CBA/CaJ

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:123675 )

N • at 5 and a half weeks and at 6 months of age, heterozygotes show no significant differences in ABR and DPOAE thresholds relative to wild-type mice