Phenotypes associated with this allele

• Allele Symbol: Dgkd^{Gt(RRT600)Byg}
• Allele Name: gene trap RRT600, BayGenomics
• Allele ID: MGI:3514143
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dgkd^Gt(RRT600)Byg/Dgkd^Gt(RRT600)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:3763530
ht2	Dgkd^Gt(RRT600)Byg/Dgkd^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3763531

Genotype
MGI:3763530

hm1

• Allelic Composition: Dgkd^{Gt(RRT600)Byg}/Dgkd^{Gt(RRT600)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

seizures ( J:126380 )

• 3 of 6 homozygotes showed discrete seizures in association with rhythmic electromyography activities, no seizures were seen in wild-type controls

• one of these mice showed bilateral ictal discharge while the other 2 showed ictal EEG activity confined to a single hemisphere

neoplasm

increased tumor incidence ( J:126380 )

• 2 of 21 homozygotes developed tumors by 15 months of age compared to no tumors in wild-type littermates

• one of these mice had squamous cell carcinoma of the tongue at 11 months of age and the other developed a hepatoma by 15 months of age

behavior/neurological

seizures ( J:126380 )

• 3 of 6 homozygotes showed discrete seizures in association with rhythmic electromyography activities, no seizures were seen in wild-type controls

• one of these mice showed bilateral ictal discharge while the other 2 showed ictal EEG activity confined to a single hemisphere

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Lennox-Gastaut syndrome		DOID:0050561	OMIM:606369	J:126380

Genotype
MGI:3763531

ht2

• Allelic Composition: Dgkd^{Gt(RRT600)Byg}/Dgkd⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

neoplasm

increased sarcoma incidence ( J:126380 )

• 2 of 28 heterozygous mice had histiocytic sarcoma by 16 months of age compared to no tumors in wild-type littermates