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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dmbt1tm1Kumc
targeted mutation 1, Robert C De Lisle
MGI:3514149
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Dmbt1tm1Kumc/Dmbt1tm1Kumc B6.129X1-Dmbt1tm1Kumc MGI:3777613
hm2
Dmbt1tm1Kumc/Dmbt1tm1Kumc involves: 129X1/SvJ * C57BL/6J MGI:3777614
cx3
Dmbt1tm1Kumc/Dmbt1tm1Kumc
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6J MGI:3777615
cx4
Dmbt1tm1Kumc/Dmbt1+
Trp53tm1Tyj/Trp53+
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6J MGI:3777616


Genotype
MGI:3777613
hm1
Allelic
Composition
Dmbt1tm1Kumc/Dmbt1tm1Kumc
Genetic
Background
B6.129X1-Dmbt1tm1Kumc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmbt1tm1Kumc mutation (1 available); any Dmbt1 mutation (111 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
N
• mice have same response severity to dextran sodium sulfate-induced colitis (DSS colitis) as wild-type
• colon morphology, weight loss and inflammatory response are similar to wild-type in DSS-induced colitis model




Genotype
MGI:3777614
hm2
Allelic
Composition
Dmbt1tm1Kumc/Dmbt1tm1Kumc
Genetic
Background
involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmbt1tm1Kumc mutation (1 available); any Dmbt1 mutation (111 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
N
• mice have same response severity to caerulein-induced acute pancreatitis as wild-type; pancreatic tissue edema, inflammation, increased tissue myeloperoxidase and serum amylase levels, inflammation, and apoptosis in response to pancreatitis is the same

neoplasm
N
• up to 1 year of age, mice do not develop tumors, with none detected in pancreas or gastrointestinal tract




Genotype
MGI:3777615
cx3
Allelic
Composition
Dmbt1tm1Kumc/Dmbt1tm1Kumc
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmbt1tm1Kumc mutation (1 available); any Dmbt1 mutation (111 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• majority of mice (86%) die early (before 9 months of age), or are euthanized due to occurrence of obvious tumor mass

neoplasm
N
• mice do not develop tumors in pancreas or gastrointestinal tract regardless of Trp53 status




Genotype
MGI:3777616
cx4
Allelic
Composition
Dmbt1tm1Kumc/Dmbt1+
Trp53tm1Tyj/Trp53+
Genetic
Background
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmbt1tm1Kumc mutation (1 available); any Dmbt1 mutation (111 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• some mice die before 9 month experimental end-point of 9 months due to development of obvious tumor mass





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory