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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Spout1tm1Mxu
targeted mutation 1, Ming Xu
MGI:3514265
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Spout1tm1Mxu/Spout1tm1Mxu involves: 129 * C57BL/6 MGI:3514282
ht2
 		Spout1tm1Mxu/Spout1+ involves: 129 * C57BL/6 MGI:3514287
cx3
 		Spout1tm1Mxu/Spout1+
Dffatm1Mxu/Dffatm1Mxu 		involves: 129 * C57BL/6 MGI:3514288


Genotype
MGI:3514282
hm1
Allelic
Composition		 Spout1tm1Mxu/Spout1tm1Mxu
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spout1tm1Mxu mutation (0 available); any Spout1 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3514287
ht2
Allelic
Composition		 Spout1tm1Mxu/Spout1+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spout1tm1Mxu mutation (0 available); any Spout1 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased sensitivity to induced cell death ( J:88144 )
• reduced apoptosis and DNA fragmentation is seen in splenocytes, thymocytes, and MEFs after treatment with apoptotic stimuli
abnormal male germ cell apoptosis ( J:88144 )
• reduced amount of spontaneous apoptosis during spermatogenesis relative to wild-type

reproductive system
abnormal male germ cell apoptosis ( J:88144 )
• reduced amount of spontaneous apoptosis during spermatogenesis relative to wild-type




Genotype
MGI:3514288
cx3
Allelic
Composition		 Spout1tm1Mxu/Spout1+
Dffatm1Mxu/Dffatm1Mxu
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dffatm1Mxu mutation (0 available); any Dffa mutation (16 available)
Spout1tm1Mxu mutation (0 available); any Spout1 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased apoptosis ( J:88144 )
• apoptosis and DNA fragmentation were essentially eliminated in splenocytes and thymocytes after treatment with apoptotic stimuli




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory