All Phenotypes Spout1<tm1Mxu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Spout1^tm1Mxu
targeted mutation 1, Ming Xu
MGI:3514265

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spout1^tm1Mxu/Spout1^tm1Mxu	involves: 129 * C57BL/6	MGI:3514282
ht2	Spout1^tm1Mxu/Spout1⁺	involves: 129 * C57BL/6	MGI:3514287
cx3	Spout1^tm1Mxu/Spout1⁺ Dffa^tm1Mxu/Dffa^tm1Mxu	involves: 129 * C57BL/6	MGI:3514288

Allelic Composition	Spout1^tm1Mxu/Spout1^tm1Mxu
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spout1^tm1Mxu mutation (0 available); any Spout1 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:88144 )

• mice die between E2.5 and E3.5

Allelic Composition	Spout1^tm1Mxu/Spout1⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spout1^tm1Mxu mutation (0 available); any Spout1 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased sensitivity to induced cell death ( J:88144 )

• reduced apoptosis and DNA fragmentation is seen in splenocytes, thymocytes, and MEFs after treatment with apoptotic stimuli

abnormal male germ cell apoptosis ( J:88144 )

• reduced amount of spontaneous apoptosis during spermatogenesis relative to wild-type

reproductive system

abnormal male germ cell apoptosis ( J:88144 )

• reduced amount of spontaneous apoptosis during spermatogenesis relative to wild-type

Allelic Composition	Spout1^tm1Mxu/Spout1⁺ Dffa^tm1Mxu/Dffa^tm1Mxu
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dffa^tm1Mxu mutation (0 available); any Dffa mutation (16 available)
Spout1^tm1Mxu mutation (0 available); any Spout1 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased apoptosis ( J:88144 )

• apoptosis and DNA fragmentation were essentially eliminated in splenocytes and thymocytes after treatment with apoptotic stimuli

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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