Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(KRT14-HPV16E7)2350Plam transgene insertion 2350, Paul F Lambert MGI:3514323 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no mice survive past weaning
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• small bilateral cataracts are seen at birth
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• an increase in apoptotic cells is seen in hair follicles
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• only about 2% of mice survive past the first 2 weeks of life
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• growth is severely stunted through the first 2 months of life; however, surviving mice eventually reach normal body size and weight
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• small bilateral cataracts are seen at birth
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• the thickness of the nucleated layer is increased in squamous epithelia in the upper digestive tract
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• squamous epithelia in the forestomach is highly invaginated
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• an increase in apoptotic cells is seen in hair follicles
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• mice appear scruffy with less dense fur
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• the fur often appears greasy and matted
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• the fur often appears greasy and matted
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• about a 5-fold increase in apoptosis primarily in the stratum granulosum and these apoptotic cells occur in patches
• squamous epithelia in the skin is highly invaginated
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• clearly seen in adult ears
• a disorganized pattern of proliferating cells is seen in the skin with many proliferating cells that are not in contact with the basement membrane present
• hyperproliferation of epithelial cells results in lateral and vertical expansion of the affected epithelium
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• first seen at P3 in most mice
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• the skin on the ears and/or snout is thickened in neonatal and adult mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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