Phenotypes associated with this allele

• Allele Symbol: Il10^tm1.1Roer
• Allele Name: targeted mutation 1.1, Axel Roers
• Allele ID: MGI:3521569
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il10^tm1.1Roer/Il10^tm1.1Roer	involves: 129P2/OlaHsd	MGI:4355203
hm2	Il10^tm1.1Roer/Il10^tm1.1Roer	involves: 129P2/OlaHsd * C57BL/6	MGI:3521688

Genotype
MGI:4355203

hm1

• Allelic Composition: Il10^tm1.1Roer/Il10^tm1.1Roer
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

spleen hyperplasia ( J:151551 )

• is observed after immunization with anti-IgD antibody

increased B cell number ( J:151551 )

• increased B cell numbers are observed after immunization with anti-IgD antibody compared to immunized controls

increased plasma cell number ( J:151551 )

• plasma cell numbers are 2-fold larger than controls seven days after immunization with anti-IgD antibody

increased T cell number ( J:151551 )

• vast majority of mice die 24 hours after LPS injection

abnormal myeloid leukocyte morphology ( J:151551 )

• increased myeloid numbers are observed after immunization with anti-IgD antibody compared to immunized controls

increased myeloid dendritic cell number ( J:151551 )

• increased myeloid dendritic numbers are observed after immunization with anti-IgD antibody compared to immunized controls

decreased circulating interleukin-10 level ( J:151551 )

• IL-10 levels are undetectable in mice immunized with anti-IgD antibodies

increased susceptibility to endotoxin shock ( J:151551 )

• vast majority of mice die 24 hours after LPS injection

homeostasis/metabolism

decreased circulating interleukin-10 level ( J:151551 )

• IL-10 levels are undetectable in mice immunized with anti-IgD antibodies

hematopoietic system

spleen hyperplasia ( J:151551 )

• is observed after immunization with anti-IgD antibody

increased B cell number ( J:151551 )

• increased B cell numbers are observed after immunization with anti-IgD antibody compared to immunized controls

increased plasma cell number ( J:151551 )

• plasma cell numbers are 2-fold larger than controls seven days after immunization with anti-IgD antibody

increased T cell number ( J:151551 )

• vast majority of mice die 24 hours after LPS injection

abnormal myeloid leukocyte morphology ( J:151551 )

• increased myeloid numbers are observed after immunization with anti-IgD antibody compared to immunized controls

increased myeloid dendritic cell number ( J:151551 )

• increased myeloid dendritic numbers are observed after immunization with anti-IgD antibody compared to immunized controls

growth/size/body

spleen hyperplasia ( J:151551 )

• is observed after immunization with anti-IgD antibody

Genotype
MGI:3521688

hm2

• Allelic Composition: Il10^tm1.1Roer/Il10^tm1.1Roer
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:94537 )

• increased sensitivity to LPS resulted in 8/10 mutants dying within 3 days after infection

digestive/alimentary system

intestinal inflammation ( J:94537 )

• 41% developed inflammatory bowel disease at 6 months of age

immune system

intestinal inflammation ( J:94537 )

• 41% developed inflammatory bowel disease at 6 months of age

abnormal hypersensitivity reaction ( J:94537 )

• displayed approximately twofold increase in ear thickness after contact with allergen 2,4-dinitrochlorobenzene (DNCB) compared to controls

abnormal cytokine secretion ( J:94537 )

• increased secretion of IFN-gamma, TNF-alpha, IL-6, and MCP-1 by stimulated splenocytes

abnormal innate immunity ( J:94537 )

• enhanced cutaneous irritant response to croton oil compared with T cell-specific IL10^tm1Roer conditional mutants

increased susceptibility to bacterial infection ( J:94537 )

• increased sensitivity to LPS compared with T cell-specific IL10^tm1Roer conditional mutants and wild-types, with 8/10 mutants dying within 3 days after infection