All Phenotypes Hap1<tm2Id> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hap1^tm2Id
targeted mutation 2, Ioannis Dragatsis
MGI:3521577

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hap1^tm2Id/Hap1^tm2Id	involves: 129S1/Sv * C57BL/6	MGI:3521641
ht2	Hap1^tm1Id/Hap1^tm2Id	involves: 129S1/Sv * C57BL/6	MGI:3521637
cn3	Hap1^tm1Id/Hap1^tm2Id Tg(Camk2a-cre)2Szi/0	involves: 129S1/Sv * C57BL/6 * CBA	MGI:3521638

Allelic Composition	Hap1^tm2Id/Hap1^tm2Id
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hap1^tm2Id mutation (0 available); any Hap1 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:94581 )

• most mutants die by P3 with only 8% surviving to 2 weeks and most of these dying before weaning

behavior/neurological

abnormal suckling behavior ( J:94581 )

• mutants have a normal rooting reflex but an increased latency time for attachment to the nipple and more mutants fail to attach to the nipple

• no milk is seen in mutant stomachs

growth/size/body

postnatal growth retardation ( J:94581 )

• mutants that survive to 2 weeks show a 70% reduction in body size

Allelic Composition	Hap1^tm1Id/Hap1^tm2Id
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hap1^tm1Id mutation (0 available); any Hap1 mutation (38 available)
Hap1^tm2Id mutation (0 available); any Hap1 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:94581 )

• most mutants die by P3 with only 8% surviving to 2 weeks and most of these dying before weaning

behavior/neurological

abnormal suckling behavior ( J:94581 )

• mutants have a normal rooting reflex but an increased latency time for attachment to the nipple and more mutants fail to attach to the nipple

• no milk is seen in mutant stomachs

growth/size/body

postnatal growth retardation ( J:94581 )

• mutants that survive to 2 weeks show a 70% reduction in body size

Allelic Composition	Hap1^tm1Id/Hap1^tm2Id Tg(Camk2a-cre)2Szi/0
Genetic Background	involves: 129S1/Sv * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

postnatal growth retardation ( J:94581 )

• postnatal lethality is no longer seen in mutants however a slight growth deficiency is seen with mutants at P21 only about 70% of the size of wild-type littermates

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