Phenotypes associated with this allele

• Allele Symbol: Ins2^tm1Delt
• Allele Name: targeted mutation 1, Louise Deltour
• Allele ID: MGI:3521584
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ins2^tm1Delt/Ins2^+	involves: 129S2/SvPas * Black Swiss	MGI:3521710
ht2	Ins2^tm1Delt/Ins2^tm1Jja	involves: 129S2/SvPas	MGI:3521711

Genotype
MGI:3521710

ht1

• Allelic Composition: Ins2^tm1Delt/Ins2⁺
• Genetic Background: involves: 129S2/SvPas * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:94589 )

• heterozygotes die around P2 with severe diabetes mellitus and ketoacidosis

endocrine/exocrine glands

decreased pancreatic alpha cell number ( J:94589 )

• at E12.5 there is an 85% decrease in the alpha cell population however the number of alpha cells is normal in neonates

absent pancreatic beta cells ( J:94589 )

• no beta cells are detected in the pancreas

small pancreatic islets ( J:94589 )

• islet size is reduced as a result of absence of beta cells

• the numbers of alpha, delta, and pancreatic polypetide cells are normal in newborn mutants

growth/size/body

postnatal growth retardation ( J:94589 )

homeostasis/metabolism

increased circulating ketone body level ( J:94589 )

• ketone bodies are detected the day after onset of suckling

dehydration ( J:94589 )

increased urine glucose level ( J:94589 )

• detected a few hours after pups begin suckiling

liver/biliary system

hepatic steatosis ( J:94589 )

renal/urinary system

increased urine glucose level ( J:94589 )

• detected a few hours after pups begin suckiling

Genotype
MGI:3521711

ht2

• Allelic Composition: Ins2^tm1Delt/Ins2^tm1Jja
• Genetic Background: involves: 129S2/SvPas

endocrine/exocrine glands

decreased pancreatic beta cell number ( J:94589 )

• no beta cells are detected in the pancreas