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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cysltr2tm1Ykn
targeted mutation 1, Yoshihide Kanaoka
MGI:3521667
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cysltr2tm1Ykn/Cysltr2tm1Ykn C57BL/6-Cysltr2tm1Ykn MGI:3527185
hm2
 		Cysltr2tm1Ykn/Cysltr2tm1Ykn C.B6-Cysltr2tm1Ykn MGI:5316010
cx3
 		Cysltr1tm1Ykn/Cysltr1tm1Ykn
Cysltr2tm1Ykn/Cysltr2tm1Ykn 		involves: BALB/c * C57BL/6 MGI:5532485
cx4
 		Cysltr1tm1Ykn/Cysltr1tm1Ykn
Cysltr2tm1Ykn/Cysltr2tm1Ykn
Oxgr1tm1(KOMP)Vlcg/Oxgr1tm1(KOMP)Vlcg 		involves: BALB/c * C57BL/6 * C57BL/6NTac MGI:5532486


Genotype
MGI:3527185
hm1
Allelic
Composition		 Cysltr2tm1Ykn/Cysltr2tm1Ykn
Genetic
Background		 C57BL/6-Cysltr2tm1Ykn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cysltr2tm1Ykn mutation (2 available); any Cysltr2 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to type I hypersensitivity reaction ( J:94488 )
• IgE-dependent plasma protein extravasation in the ear is reduced by about 65% 30 minutes after antigen challenge, however zymosan A-induced peritoneal inflammation is normal

respiratory system
pulmonary fibrosis ( J:94488 )
• lung tissue from bleomycin-treated homozygotes had less septal thickening, with fewer monocytes/macrophages, giant cells, fibroblasts, and eosinophils, and less extracellular matris deposition compared to wild-type mice
• the area of the lower lobes with alveolar septal thickening in bleomycin traeted mutant mice is reduced to 39% of wild-type

homeostasis/metabolism
abnormal prostaglandin level ( J:94488 )
• bleomycin treatment did not increase prostaglandin E2 levels in mutant mice




Genotype
MGI:5316010
hm2
Allelic
Composition		 Cysltr2tm1Ykn/Cysltr2tm1Ykn
Genetic
Background		 C.B6-Cysltr2tm1Ykn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cysltr2tm1Ykn mutation (2 available); any Cysltr2 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
autoimmune response ( J:182213 )
• mutants exhibit impaired epidermal and dermal thickening and collagen deposition in OVA-sensitized skin compared to wild-type mice
• however, dermal infiltration by CD4+ cells and eosinophils is comparable to wild-type controls

integument
abnormal skin physiology ( J:182213 )
• mutants exhibit impaired epidermal and dermal thickening and collagen deposition in OVA-sensitized skin compared to wild-type mice




Genotype
MGI:5532485
cx3
Allelic
Composition		 Cysltr1tm1Ykn/Cysltr1tm1Ykn
Cysltr2tm1Ykn/Cysltr2tm1Ykn
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cysltr1tm1Ykn mutation (2 available); any Cysltr1 mutation (11 available)
Cysltr2tm1Ykn mutation (2 available); any Cysltr2 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immune system physiology ( J:198383 )
• at high doses, mice exhibit enhanced leukotriene E4 ligand (LTE4)-induced ear edema compared with wild-type mice
• at high doses, mice exhibit slightly reduced leukotriene C4 ligand (LTC4)-induced ear edema compared with wild-type mice




Genotype
MGI:5532486
cx4
Allelic
Composition		 Cysltr1tm1Ykn/Cysltr1tm1Ykn
Cysltr2tm1Ykn/Cysltr2tm1Ykn
Oxgr1tm1(KOMP)Vlcg/Oxgr1tm1(KOMP)Vlcg
Genetic
Background		 involves: BALB/c * C57BL/6 * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cysltr1tm1Ykn mutation (2 available); any Cysltr1 mutation (11 available)
Cysltr2tm1Ykn mutation (2 available); any Cysltr2 mutation (33 available)
Oxgr1tm1(KOMP)Vlcg mutation (1 available); any Oxgr1 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immune system physiology ( J:198383 )
• at high doses, mice exhibit reduced leukotriene E4 ligand (LTE4) or leukotriene C4 ligand (LTC4)-induced ear edema compared with wild-type mice
• at low and intermediate doses, mice fail to exhibit leukotriene E4 ligand (LTE4)-, leukotriene C4 ligand (LTC4)- or leukotriene D4 (LTD4)-induced ear edema unlike wild-type mice




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory