Phenotypes associated with this allele

• Allele Symbol: Kcnn4^tm1Jemn
• Allele Name: targeted mutation 1, James E Melvin
• Allele ID: MGI:3521668
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcnn4^tm1Jemn/Kcnn4^tm1Jemn	involves: 129S1/Sv * C57BL/6J	MGI:3527178

Genotype
MGI:3527178

hm1

• Allelic Composition: Kcnn4^tm1Jemn/Kcnn4^tm1Jemn
• Genetic Background: involves: 129S1/Sv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased parotid gland size ( J:94478 )

• in homozygous males the weight of the parotid gland is significantly increased, however no change in salivary flow or composition is seen

hematopoietic system

abnormal hematopoietic system physiology ( J:94478 )

• A23187-stimulated, clotrimazole sensitive uptake of ⁸⁶Rb into red blood cells is nearly eliminated in homozygous mutants and A23187 has no effect on the tonicity at which 50% of mutant red cells lyse

abnormal T cell physiology ( J:94478 )

• shrinkage of T lymphocytes induced by the Ca²⁺ ionophore, ionomycin, is greatly reduced

immune system

abnormal T cell physiology ( J:94478 )

• shrinkage of T lymphocytes induced by the Ca²⁺ ionophore, ionomycin, is greatly reduced

digestive/alimentary system

increased parotid gland size ( J:94478 )

• in homozygous males the weight of the parotid gland is significantly increased, however no change in salivary flow or composition is seen