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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ahrtm3Bra
targeted mutation 3, Christopher A Bradfield
MGI:3521676
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ahrtm3Bra/Ahrtm3Bra involves: 129/Sv * C57BL/6J * DBA/2 MGI:3521905


Genotype
MGI:3521905
hm1
Allelic
Composition
Ahrtm3Bra/Ahrtm3Bra
Genetic
Background
involves: 129/Sv * C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ahrtm3Bra mutation (0 available); any Ahr mutation (112 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• a patent ductus venosus (shunting blood around the liver) was seen in 22/25 mutants
• exposure to a non-teratogenic concentration of dioxin on E12.5, E14.5, E16.5 or E18.5 resulted in closure of the ductus venosus in all mutants

homeostasis/metabolism
• a 7-fold lower increase in ethoxyresorufin-O-deethylase activity is seen compared to Ahrd homozygotes

cellular
• a patent ductus venosus (shunting blood around the liver) was seen in 22/25 mutants
• exposure to a non-teratogenic concentration of dioxin on E12.5, E14.5, E16.5 or E18.5 resulted in closure of the ductus venosus in all mutants





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory