cardiovascular system
• a patent ductus venosus (shunting blood around the liver) was seen in 22/25 mutants
• exposure to a non-teratogenic concentration of dioxin on E12.5, E14.5, E16.5 or E18.5 resulted in closure of the ductus venosus in all mutants
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homeostasis/metabolism
• a 7-fold lower increase in ethoxyresorufin-O-deethylase activity is seen compared to Ahrd homozygotes
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cellular
• a patent ductus venosus (shunting blood around the liver) was seen in 22/25 mutants
• exposure to a non-teratogenic concentration of dioxin on E12.5, E14.5, E16.5 or E18.5 resulted in closure of the ductus venosus in all mutants
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