Phenotypes associated with this allele

• Allele Symbol: Mmp13^tm1Werb
• Allele Name: targeted mutation 1, Zena Werb
• Allele ID: MGI:3521687
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mmp13^tm1Werb/Mmp13^tm1Werb Tg(Col1a1-cre)1Kry/0	involves: 129S2/SvPas	MGI:3522356
cn2	Mmp13^tm1Werb/Mmp13^tm1Werb Tg(Col2a1-cre)1Rsjo/0	involves: 129S2/SvPas	MGI:3522357
cn3	Mmp13^tm1Werb/Mmp13^tm1Werb Tg(CMV-cre)1Cgn/0	involves: 129S2/SvPas * BALB/cJ * C57BL/6	MGI:3652794

Genotype
MGI:3522356

cn1

• Allelic Composition: Mmp13^tm1Werb/Mmp13^tm1Werb; Tg(Col1a1-cre)1Kry/0
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal trabecular bone morphology ( J:94460 )

• the volume of trabecular bone is increased however the size of the hypertrophic chondrocyte zone is normal

Genotype
MGI:3522357

cn2

• Allelic Composition: Mmp13^tm1Werb/Mmp13^tm1Werb; Tg(Col2a1-cre)1Rsjo/0
• Genetic Background: involves: 129S2/SvPas

skeleton

increased width of hypertrophic chondrocyte zone ( J:94460 )

• the number of hypertrophic chondrocytes is increased

abnormal trabecular bone morphology ( J:94460 )

• the spicules of trabecular bone are irregular in shape and length, however trabecular bone volume is normal

Genotype
MGI:3652794

cn3

• Allelic Composition: Mmp13^tm1Werb/Mmp13^tm1Werb; Tg(CMV-cre)1Cgn/0
• Genetic Background: involves: 129S2/SvPas * BALB/cJ * C57BL/6

integument

integument phenotype ( J:104953 )

N • epidermal architecture and dermal composition are normal and show no differences in efficiency of re-epithelialization, inflammatory response, granulation tissue formation, angiogenesis, and restoration of basement membrane, indicating that skin homeostasis and tissue remodeling processes are normal