Phenotypes associated with this allele

• Allele Symbol: Hoxa13^tm1Jwi
• Allele Name: targeted mutation 1, Jeffrey W Innis
• Allele ID: MGI:3521726
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxa13^tm1Jwi/Hoxa13^tm1Jwi	involves: 129S7/SvEvBrd	MGI:3521745
ht2	Hoxa13^tm1Jwi/Hoxa13^+	involves: 129S7/SvEvBrd	MGI:3521748

Genotype
MGI:3521745

hm1

• Allelic Composition: Hoxa13^tm1Jwi/Hoxa13^tm1Jwi
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:94412 )

• none survived to birth

limbs/digits/tail

oligodactyly ( J:94412 )

• loss of digit one (the thumb or hallux) in E13.5 forelimb and hindlimb buds, and were indistinguishable from Hoxa13 null mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hand-foot-genital syndrome		DOID:0060739	OMIM:140000	J:94412

Genotype
MGI:3521748

ht2

• Allelic Composition: Hoxa13^tm1Jwi/Hoxa13⁺
• Genetic Background: involves: 129S7/SvEvBrd

limbs/digits/tail

brachydactyly ( J:94412 )

• shortened first digit in E13.5 forelimb and hindlimb buds and shortened first digit or nail of the hindfoot

syndactyly ( J:94412 )

• occasional cutaneous syndactyly between digits two and three

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hand-foot-genital syndrome		DOID:0060739	OMIM:140000	J:94412