All Phenotypes Prop1<tm1Sac> MGI Mouse

premature death ( J:94409 )

• a fraction of pups with a higher contribution of the C57BL/6J background display lethargy and die precipitously between weaning and adulthood

neonatal lethality, incomplete penetrance ( J:94409 )

• some mutants become cyanotic and die within 0.5 -4 hours after birth

postnatal lethality, incomplete penetrance ( J:94409 )

• about half the expected number of homozygous mutants (14% pups) are found 2 weeks after birth

• Background Sensitivity: survival decreases to 6.7% of pups after 2 generations of backcrossing to 129S1/SvImJ and increases to 17.5% of pups after 2 generations of backcrossing to C57BL/6J

lethargy ( J:94409 )

• a fraction of pups with a higher contribution of the C57BL/6J background display lethargy and die between weaning and adulthood

adenohypophysis hypoplasia ( J:94409 )

• the anterior pituitary gland consists of only a few cell layers

abnormal neurohypophysis morphology ( J:94409 )

• dysmorphology of the dorsal pituitary is seen at E14.5 - E15.5

pituitary gland hypoplasia ( J:94409 )

• ventral hypoplasia is seen at E14.5 - E15.5

small thyroid gland ( J:94409 )

• adults have underdeveloped thyroid glands

hypopituitarism ( J:94409 )

• anterior pituitary hormone deficiencies are evident during gestation with few or no cells positive for TSH, GH, or LH and reduced levels of FSH, however mutants crossed onto the C57BL/6J background have normal levels of gonadotropes

proportional dwarf ( J:94409 )

• surviving mutants are dwarfs, with growth retardation detectable by P10

increased circulating corticosterone level ( J:94409 )

• corticosterone levels are normal before birth but significantly elevated after birth

cyanosis ( J:94409 )

small gonad ( J:94409 )

• adults have underdeveloped gonads

abnormal pulmonary alveolus morphology ( J:94409 )

• the lungs of all cyanotic pups contain excess mesenchymal tissue, with cuboidal rather than squamous cells lining the uninflated alveoli

atelectasis ( J:94409 )

• the lungs of all cyanotic pups are ateletatic

abnormal respiratory system physiology ( J:94409 )

respiratory distress ( J:94409 )

• irregular breathing coming in gasps with air bubbles seen in the intestines

• seen in pups that fail to survive and is more frequent in pups with a higher contribution of the 129S1/SvImJ background compared to pups with a higher contribution of the C57BL/6J background

abnormal surfactant secretion ( J:94409 )

• about a 2-fold decrease in levels of surfactant B is seen in lungs from mutants with a higher contribution of the 129S1/SvImJ background