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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Uba7tm1Dez
targeted mutation 1, Dong-Er Zhang
MGI:3521787
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Uba7tm1Dez/Uba7tm1Dez involves: 129/Sv * C57BL/6 MGI:3830334
cx2
 		Uba7tm1Dez/Uba7tm1Dez
Usp18tm1Dez/Usp18tm1Dez 		involves: 129 * C57BL/6 MGI:3830335


Genotype
MGI:3830334
hm1
Allelic
Composition		 Uba7tm1Dez/Uba7tm1Dez
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Uba7tm1Dez mutation (0 available); any Uba7 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:3830335
cx2
Allelic
Composition		 Uba7tm1Dez/Uba7tm1Dez
Usp18tm1Dez/Usp18tm1Dez
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Uba7tm1Dez mutation (0 available); any Uba7 mutation (36 available)
Usp18tm1Dez mutation (1 available); any Usp18 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased sensitivity to induced cell death ( J:144149 )
• bone marrow cells have almost double the amount of apoptotic cells as controls when cultured with interferon-alpha/beta
• the homozygote null Uba7tm1Dzh alleles do not rescue the increased sensitivity of Usp18tm1Dzh homozygote cells to IFN-mediated apoptosis




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory