Phenotypes associated with this allele

• Allele Symbol: Rock1^tm1Leiw
• Allele Name: targeted mutation 1, Lei Wei
• Allele ID: MGI:3521801
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rock1^tm1Leiw/Rock1^tm1Leiw	FVB.129S7-Rock1^tm1Leiw	MGI:3687021
ht2	Rock1^tm1Leiw/Rock1^+	FVB.129S7-Rock1^tm1Leiw	MGI:3687020
cx3	Lepr^db/Lepr^db Rock1^tm1Leiw/Rock1^tm1Leiw	involves: 129S7/SvEvBrd * C57BLKS/J * FVB/N	MGI:5316083

Genotype
MGI:3687021

hm1

• Allelic Composition: Rock1^tm1Leiw/Rock1^tm1Leiw
• Genetic Background: FVB.129S7-Rock1^tm1Leiw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality at implantation, incomplete penetrance ( J:111469 )

• about 50 to 60% of embryos die before implantation or early postimplantation

cardiovascular system

abnormal cardiovascular system physiology ( J:111469 )

• homozygotes undergoing transverse aortic banding to induce concentric cardiac hypertrophy show a smaller increase in cardiac fibrosis and reduced expression of a variety of extracellular matrix proteins and fibrogenic cytokines at 3 weeks after banding than wild-type, however hypertrophic responses are not impaired and cardiac dimension and contractile function are preserved

increased heart rate ( J:111469 )

• exhibit about a 20% increase in heart rate after induction of pressure overload

Genotype
MGI:3687020

ht2

• Allelic Composition: Rock1^tm1Leiw/Rock1⁺
• Genetic Background: FVB.129S7-Rock1^tm1Leiw

mortality/aging

embryonic lethality at implantation, incomplete penetrance ( J:111469 )

• about 30% of embryos die before implantation or early postimplantation

Genotype
MGI:5316083

cx3

• Allelic Composition: Lepr^db/Lepr^db; Rock1^tm1Leiw/Rock1^tm1Leiw
• Genetic Background: involves: 129S7/SvEvBrd * C57BLKS/J * FVB/N

renal/urinary system

renal/urinary system phenotype ( J:182287 )

N • mice treated with streptozotocin to induce diabetes do not exhibit podocyte loss unlike similarly treated Lepr^db homozygotes

increased renal glomerulus apoptosis ( J:182287 )

• mice treated with streptozotocin to induce diabetes exhibit glomerular apoptosis but not as much as in similarly treated Lepr^db homozygotes

enlarged kidney ( J:182287 )

• in mice treated with streptozotocin to induce diabetes as in similarly treated Lepr^db homozygotes

increased kidney weight ( J:182287 )

• in mice treated with streptozotocin to induce diabetes as in similarly treated Lepr^db homozygotes

albuminuria ( J:182287 )

• in mice treated with streptozotocin to induce diabetes but not as much as in similarly treated Lepr^db homozygotes

increased renal glomerulus basement membrane thickness ( J:182287 )

• in mice treated with streptozotocin to induce diabetes but not as much as in similarly treated Lepr^db homozygotes

expanded mesangial matrix ( J:182287 )

• in mice treated with streptozotocin to induce diabetes as in similarly treated Lepr^db homozygotes

homeostasis/metabolism

hyperglycemia ( J:182287 )

• in mice treated with streptozotocin to induce diabetes as in similarly treated Lepr^db homozygotes

albuminuria ( J:182287 )

• in mice treated with streptozotocin to induce diabetes but not as much as in similarly treated Lepr^db homozygotes

growth/size/body

increased body size ( J:182287 )

• in mice treated with streptozotocin to induce diabetes as in similarly treated Lepr^db homozygotes

increased body weight ( J:182287 )

• in mice treated with streptozotocin to induce diabetes as in similarly treated Lepr^db homozygotes

enlarged kidney ( J:182287 )

• in mice treated with streptozotocin to induce diabetes as in similarly treated Lepr^db homozygotes

increased kidney weight ( J:182287 )

• in mice treated with streptozotocin to induce diabetes as in similarly treated Lepr^db homozygotes

cellular

increased renal glomerulus apoptosis ( J:182287 )

• mice treated with streptozotocin to induce diabetes exhibit glomerular apoptosis but not as much as in similarly treated Lepr^db homozygotes

abnormal mitochondrial physiology ( J:182287 )

• mice treated with streptozotocin to induce diabetes exhibit mitochondrial reactive oxygen species production but not as much as in similarly treated Lepr^db homozygotes

• mice treated with streptozotocin to induce diabetes exhibit mitochondrial fission but not as much as in similarly treated Lepr^db homozygotes

oxidative stress ( J:182287 )

• mice treated with streptozotocin to induce diabetes exhibit mitochondrial reactive oxygen species production but not as much as in similarly treated Lepr^db homozygotes