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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slc46a2tm1Moki
targeted mutation 1, Moon Kim
MGI:3521803
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Slc46a2tm1Moki/Slc46a2tm1Moki involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3812195
cx2
 		Rag1tm1Mom/Rag1tm1Mom
Slc46a2tm1Moki/Slc46a2+
Tg(TcraB12,TcrbB12)1Rest/0 		involves: 129 * C57BL/6 MGI:3812196


Genotype
MGI:3812195
hm1
Allelic
Composition		 Slc46a2tm1Moki/Slc46a2tm1Moki
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc46a2tm1Moki mutation (0 available); any Slc46a2 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
thymus hypoplasia ( J:140121 )
• about one-third of mice have slightly lower thymic cell numbers at 6 weeks of age

hematopoietic system
thymus hypoplasia ( J:140121 )
• about one-third of mice have slightly lower thymic cell numbers at 6 weeks of age

endocrine/exocrine glands
thymus hypoplasia ( J:140121 )
• about one-third of mice have slightly lower thymic cell numbers at 6 weeks of age




Genotype
MGI:3812196
cx2
Allelic
Composition		 Rag1tm1Mom/Rag1tm1Mom
Slc46a2tm1Moki/Slc46a2+
Tg(TcraB12,TcrbB12)1Rest/0
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (49 available); any Rag1 mutation (123 available)
Slc46a2tm1Moki mutation (0 available); any Slc46a2 mutation (22 available)
Tg(TcraB12,TcrbB12)1Rest mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T cell apoptosis ( J:140121 )
• massive cell death of double negative as well as CD4+ and/or CD8+ thymocytes occur in these mice
thymus hypoplasia ( J:140121 )
• thymic cellularity is reduced by about 5-fold compared to transgenic Rag1 null mice
decreased double-positive T cell number ( J:140121 )
• double-positive T cells are absent in the thymus
arrested T cell differentiation ( J:140121 )
• T cells are arrested in the DN3 stage

hematopoietic system
increased T cell apoptosis ( J:140121 )
• massive cell death of double negative as well as CD4+ and/or CD8+ thymocytes occur in these mice
thymus hypoplasia ( J:140121 )
• thymic cellularity is reduced by about 5-fold compared to transgenic Rag1 null mice
decreased double-positive T cell number ( J:140121 )
• double-positive T cells are absent in the thymus
arrested T cell differentiation ( J:140121 )
• T cells are arrested in the DN3 stage

cellular
increased T cell apoptosis ( J:140121 )
• massive cell death of double negative as well as CD4+ and/or CD8+ thymocytes occur in these mice

endocrine/exocrine glands
thymus hypoplasia ( J:140121 )
• thymic cellularity is reduced by about 5-fold compared to transgenic Rag1 null mice




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory