Phenotypes associated with this allele

• Allele Symbol: Fosl2^tm1Wag
• Allele Name: targeted mutation 1, Erwin F Wagner
• Allele ID: MGI:3521815
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fosl2^tm1Wag/Fosl2^tm1Wag	involves: 129 * C57BL/6	MGI:3522177

Genotype
MGI:3522177

hm1

• Allelic Composition: Fosl2^tm1Wag/Fosl2^tm1Wag
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:94393 )

• die during the first week after birth

growth/size/body

postnatal growth retardation ( J:94393 )

• growth retardation after P1

skeleton

abnormal vertebrae morphology ( J:94393 )

• less calcified matrix was deposited in vertebrae at E16.5

abnormal vertebral arch morphology ( J:94393 )

• at E14.5, cells of the primordial arches of developing vertebrae appeared smaller and less hypertrophic

abnormal cartilage morphology ( J:94393 )

abnormal skeleton development ( J:94393 )

decreased width of hypertrophic chondrocyte zone ( J:94393 )

• reduced zone of hypertrophic chondrocytes in E14.5-P4 femoral and tibial growth plates but not at E13.5

abnormal long bone epiphysis morphology ( J:94393 )

• slight reduction at E15.5 and more pronounced reduction at E17.5 of extracellular matrix deposition in the epiphysis

abnormal vertebrae development ( J:94393 )

• delayed development of vertebral columns

abnormal chondrocyte differentiation ( J:94393 )

• impaired chondrocyte differentiation into mature hypertrophic chondrocytes

delayed endochondral bone ossification ( J:94393 )

• initiation of endochondral ossification of the spine was delayed for 1-2 days