Phenotypes associated with this allele

• Allele Symbol: Met^tm1Gvw
• Allele Name: targeted mutation 1, George Vande Woude
• Allele ID: MGI:3521826
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Met^tm1Gvw/Met^tm1Gvw	involves: 129 * C57BL/6J	MGI:3521978
ht2	Met^tm1Gvw/Met^+	involves: 129 * C57BL/6J	MGI:3521979

Genotype
MGI:3521978

hm1

• Allelic Composition: Met^tm1Gvw/Met^tm1Gvw
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:94722 )

• viable embryos were not observed after E6.5

Genotype
MGI:3521979

ht2

• Allelic Composition: Met^tm1Gvw/Met⁺
• Genetic Background: involves: 129 * C57BL/6J

neoplasm

increased tumor incidence ( J:94722 )

• 58.8% tumor incidence compared to 44.4% in controls, with some developing multiple cancers

increased lymphoma incidence ( J:94722 )

• increased incidence of lymphomas, especially histiocytic sarcomas

increased histiocytic sarcoma incidence ( J:94722 )

increased carcinoma incidence ( J:94722 )

• increased incidence of various carcinomas including transitional cell and squamous cell carcinoma

increased squamous cell carcinoma incidence ( J:94722 )

cellular

chromosome breakage ( J:94722 )

• trisomy and tetrasomy of chromosome 6 and duplication of the mutant Met allele were observed in tumors

immune system

glomerulonephritis ( J:94722 )

• infrequent to moderate incidence of glomerulonephritis

renal/urinary system

glomerulonephritis ( J:94722 )

• infrequent to moderate incidence of glomerulonephritis

hydronephrosis ( J:94722 )

• infrequent to moderate incidence of hydronephrosis