Phenotypes associated with this allele

• Allele Symbol: Met^tm2Gvw
• Allele Name: targeted mutation 2, George Vande Woude
• Allele ID: MGI:3521827
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Met^tm2Gvw/Met^tm2Gvw	involves: 129 * C57BL/6J	MGI:3521980
ht2	Met^tm2Gvw/Met^+	involves: 129 * C57BL/6J	MGI:3521982

Genotype
MGI:3521980

hm1

• Allelic Composition: Met^tm2Gvw/Met^tm2Gvw
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:94722 )

• viable embryos were not observed after E6.5

Genotype
MGI:3521982

ht2

• Allelic Composition: Met^tm2Gvw/Met⁺
• Genetic Background: involves: 129 * C57BL/6J

mortality/aging

premature death ( J:94722 )

• shorter lifespan (15.9 months) compared to controls (20.5 months)

neoplasm

increased tumor incidence ( J:94722 )

• 89.5% tumor incidence compared to 44.4% in controls, with some developing multiple cancers

increased lymphoma incidence ( J:94722 )

• 32% developed lymphomas, mainly histiocytic sarcomas

increased histiocytic sarcoma incidence ( J:94722 )

increased hemangiosarcoma incidence ( J:94722 )

• 63% developed sarcomas, mainly hemangiosarcomas

cellular

chromosome breakage ( J:94722 )

• trisomy and tetrasomy of chromosome 6 and duplication of the mutant Met allele were observed in tumors

immune system

glomerulonephritis ( J:94722 )

• infrequent to moderate incidence of glomerulonephritis

renal/urinary system

glomerulonephritis ( J:94722 )

• infrequent to moderate incidence of glomerulonephritis

hydronephrosis ( J:94722 )

• infrequent to moderate incidence of hydronephrosis