Phenotypes associated with this allele

• Allele Symbol: Met^tm4Gvw
• Allele Name: targeted mutation 4, George Vande Woude
• Allele ID: MGI:3521830
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Met^tm4Gvw/Met^tm4Gvw	involves: 129 * C57BL/6J	MGI:3521987
ht2	Met^tm4Gvw/Met^+	involves: 129 * C57BL/6J	MGI:3521988
ht3	Met^tm4Gvw/Met^+	involves: 129 * C57BL/6J * FVB/N	MGI:5565367

Genotype
MGI:3521987

hm1

• Allelic Composition: Met^tm4Gvw/Met^tm4Gvw
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:94722 )

• viable embryos are not observed after E13.5

Genotype
MGI:3521988

ht2

• Allelic Composition: Met^tm4Gvw/Met⁺
• Genetic Background: involves: 129 * C57BL/6J

neoplasm

increased tumor incidence ( J:94722 )

• 50% tumor incidence compared to 44.4% in controls

increased lymphoma incidence ( J:94722 )

increased sarcoma incidence ( J:94722 )

• developed various sarcomas

cellular

chromosome breakage ( J:94722 )

• trisomy and tetrasomy of chromosome 6 and duplication of the mutant Met allele were observed in tumors

immune system

glomerulonephritis ( J:94722 )

• infrequent to moderate incidence of glomerulonephritis

renal/urinary system

glomerulonephritis ( J:94722 )

• infrequent to moderate incidence of glomerulonephritis

hydronephrosis ( J:94722 )

• infrequent to moderate incidence of hydronephrosis

Genotype
MGI:5565367

ht3

• Allelic Composition: Met^tm4Gvw/Met⁺
• Genetic Background: involves: 129 * C57BL/6J * FVB/N

neoplasm

increased mammary gland tumor incidence ( J:151890 )

♀ • both nulliparous and multiparous females develop mammary tumors with high penetrance

♀ • mammary pads from 6- to 8-month old females show no evidence of preneoplastic growth, indicating that tumor growth is extremely rapid after initiation

♀ • mammary tumors show diverse histology with basal characteristics and include mammary adenosquamous carcinoma with solid and tubular patterns, mammary squamous cell carcinoma, mammary myoepithelioma, hamangiosarcoma, mammary adenocarcinoma with squamous metaplasia

♀ • solid features are present in 30% of tumors, but in several cases, the solid phenotype is intermixed with squamous metaplastic cells

♀ • significant squamous metaplasia is seen in 65% of mammary tumors

♀ • tumors are often estrogen receptor-positive and progesterone receptor-negative

increased mammary adenocarcinoma incidence ( J:151890 )

♀ • mammary adenocarcinoma with squamous metaplasia or/and with solid patterns

♀ • mammary adenocarcinomas show high levels of Met amplification and trisomy

increased squamous cell carcinoma incidence ( J:151890 )

♀ • mammary squamous cell carcinoma

increased sarcoma incidence ( J:151890 )

♀ • undifferentiated mammary sarcomas

increased hemangiosarcoma incidence ( J:151890 )

♀ • mammary hamangiosarcoma

increased myoepithelioma incidence ( J:151890 )

♀ • mammary myoepithelioma

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:151890 )

♀ • both nulliparous and multiparous females develop mammary tumors with high penetrance

♀ • mammary pads from 6- to 8-month old females show no evidence of preneoplastic growth, indicating that tumor growth is extremely rapid after initiation

♀ • mammary tumors show diverse histology with basal characteristics and include mammary adenosquamous carcinoma with solid and tubular patterns, mammary squamous cell carcinoma, mammary myoepithelioma, hamangiosarcoma, mammary adenocarcinoma with squamous metaplasia

♀ • solid features are present in 30% of tumors, but in several cases, the solid phenotype is intermixed with squamous metaplastic cells

♀ • significant squamous metaplasia is seen in 65% of mammary tumors

♀ • tumors are often estrogen receptor-positive and progesterone receptor-negative

increased mammary adenocarcinoma incidence ( J:151890 )

♀ • mammary adenocarcinoma with squamous metaplasia or/and with solid patterns

♀ • mammary adenocarcinomas show high levels of Met amplification and trisomy

integument

increased mammary gland tumor incidence ( J:151890 )

♀ • both nulliparous and multiparous females develop mammary tumors with high penetrance

♀ • mammary pads from 6- to 8-month old females show no evidence of preneoplastic growth, indicating that tumor growth is extremely rapid after initiation

♀ • mammary tumors show diverse histology with basal characteristics and include mammary adenosquamous carcinoma with solid and tubular patterns, mammary squamous cell carcinoma, mammary myoepithelioma, hamangiosarcoma, mammary adenocarcinoma with squamous metaplasia

♀ • solid features are present in 30% of tumors, but in several cases, the solid phenotype is intermixed with squamous metaplastic cells

♀ • significant squamous metaplasia is seen in 65% of mammary tumors

♀ • tumors are often estrogen receptor-positive and progesterone receptor-negative

increased mammary adenocarcinoma incidence ( J:151890 )

♀ • mammary adenocarcinoma with squamous metaplasia or/and with solid patterns

♀ • mammary adenocarcinomas show high levels of Met amplification and trisomy

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:151890