Phenotypes associated with this allele

• Allele Symbol: Cyfip1^Gt(XG769)Byg
• Allele Name: gene trap XG769, Bay Genomics
• Allele ID: MGI:3521835
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cyfip1^Gt(XG769)Byg/Cyfip1^Gt(XG769)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:4830278

Genotype
MGI:4830278

hm1

• Allelic Composition: Cyfip1^Gt(XG769)Byg/Cyfip1^Gt(XG769)Byg
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:163586 )

• embryonic development arrest occurs at around 8.5dpc

embryo

abnormal rostral-caudal body axis extension ( J:163586 )

• the anterior posterior axis of the mutant embryos was not able to further elongate

open neural tube ( J:163586 )

• neural tube closure was not observed in mutant embryos by 9.5dpc

kinked neural tube ( J:163586 )

delayed somite formation ( J:163586 )

• mutant embryos had only 6-12 somties at 9.5dpc, which is the somite number for the normal embryos at 8.5dpc

impaired somite development ( J:163586 )

• although the somite structures were visible, they appeared disorganized

nervous system

open neural tube ( J:163586 )

• neural tube closure was not observed in mutant embryos by 9.5dpc

kinked neural tube ( J:163586 )