Phenotypes associated with this allele

• Allele Symbol: Adcyap1^tm1Clw
• Allele Name: targeted mutation 1, Christopher S Colwell
• Allele ID: MGI:3521845
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adcyap1^tm1Clw/Adcyap1^tm1Clw	B6.129S4-Adcyap1^tm1Clw	MGI:5471630
hm2	Adcyap1^tm1Clw/Adcyap1^tm1Clw	involves: 129S4/SvJae * C57BL/6	MGI:3521908

Genotype
MGI:5471630

hm1

• Allelic Composition: Adcyap1^tm1Clw/Adcyap1^tm1Clw
• Genetic Background: B6.129S4-Adcyap1^tm1Clw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased susceptibility to dopaminergic neuron neurotoxicity ( J:194151 )

increased microglial cell activation ( J:194151 )

• saline-treated mice exhibit an increase in number of large diameter microglia (activated) and a decrease in number of small diameter microglia (resting) as compared to saline-treated wild type; no significant changes are observed between paraquat-treated mutant and control mice

decreased dopaminergic neuron number ( J:194151 )

• mutant mice exhibit a 30% reduction of tyrosine hydroxylase (TH)-positive neurons in the substantia nigra following a single dose (10 mg/kg) of the insecticide paraquat, although total number of neurons is not reduced

immune system

increased T-helper 17 cell number ( J:194151 )

• a single dose (10 mg/kg) of the insecticide paraquat increased numbers of Th17 cells in both spleen and blood, but not in lymph nodes

abnormal T cell activation ( J:194151 )

• induction of regulatory T cells is impaired in lymph nodes following administration of paraquat

abnormal regulatory T cell physiology ( J:194151 )

• induction of regulatory T cells is impaired in lymph nodes following administration of paraquat

increased microglial cell activation ( J:194151 )

• saline-treated mice exhibit an increase in number of large diameter microglia (activated) and a decrease in number of small diameter microglia (resting) as compared to saline-treated wild type; no significant changes are observed between paraquat-treated mutant and control mice

homeostasis/metabolism

increased susceptibility to dopaminergic neuron neurotoxicity ( J:194151 )

hematopoietic system

increased T-helper 17 cell number ( J:194151 )

• a single dose (10 mg/kg) of the insecticide paraquat increased numbers of Th17 cells in both spleen and blood, but not in lymph nodes

abnormal T cell activation ( J:194151 )

• induction of regulatory T cells is impaired in lymph nodes following administration of paraquat

abnormal regulatory T cell physiology ( J:194151 )

• induction of regulatory T cells is impaired in lymph nodes following administration of paraquat

increased microglial cell activation ( J:194151 )

• saline-treated mice exhibit an increase in number of large diameter microglia (activated) and a decrease in number of small diameter microglia (resting) as compared to saline-treated wild type; no significant changes are observed between paraquat-treated mutant and control mice

cellular

increased susceptibility to dopaminergic neuron neurotoxicity ( J:194151 )

Genotype
MGI:3521908

hm2

• Allelic Composition: Adcyap1^tm1Clw/Adcyap1^tm1Clw
• Genetic Background: involves: 129S4/SvJae * C57BL/6

mortality/aging

preweaning lethality, incomplete penetrance ( J:94880 )

• 50-80% of the expected number of homozygotes are found at the time of genotyping

behavior/neurological

increased locomotor activity ( J:94880 )

• increased wheel-running activity is seen with a 12:12 light:dark cycle

shortened circadian behavior period ( J:94880 )

• the free running period is about 20 minutes shorter, however no difference in synchronization to a light dark cycle or responding to shifts in the light dark cycle are seen

abnormal circadian behavior phase ( J:94880 )

• a significant shortening of the phase angle of entrainment is seen

• in constant dark, a significant reduction in the phase advance induced by a single discrete light treatment is seen when either bright or dim light is used