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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Erbb2tm6(Erbb2)Mul
targeted mutation 6, William J Muller
MGI:3521859
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Erbb2tm6(Erbb2)Mul/Erbb2tm6(Erbb2)Mul involves: 129S1/Sv * 129X1/SvJ * BALB/c MGI:3522497
ht2
Erbb2tm6(Erbb2)Mul/Erbb2tm1Haus involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c MGI:3522575


Genotype
MGI:3522497
hm1
Allelic
Composition
Erbb2tm6(Erbb2)Mul/Erbb2tm6(Erbb2)Mul
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2tm6(Erbb2)Mul mutation (0 available); any Erbb2 mutation (61 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• homozygotes are normal, healthy, and fertile




Genotype
MGI:3522575
ht2
Allelic
Composition
Erbb2tm6(Erbb2)Mul/Erbb2tm1Haus
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2tm1Haus mutation (0 available); any Erbb2 mutation (61 available)
Erbb2tm6(Erbb2)Mul mutation (0 available); any Erbb2 mutation (61 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die shortly after birth struggling unsuccessfully to breathe

respiratory system

nervous system
• phrenic nerves are thinned, disorganized, and discontinuous or incomplete and they lack an apparent main nerve trunk from which smaller presynaptic branches originate
• diaphragm muscle is very poorly innervated by the phrenic nerve

cellular





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory