All Phenotypes Top2b<tm2.1Jcw> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Top2b^tm2.1Jcw
targeted mutation 2.1, James C Wang
MGI:3521923

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Top2b^tm2.1Jcw/Top2b^tm2.1Jcw	involves: 129S4/SvJae * 129S6/SvEvTac	MGI:3521930
cn2	Top2b^tm2Jcw/Top2b^tm2.1Jcw Foxg1^tm1(cre)Skm/Foxg1⁺	involves: 129S4/SvJae * 129S6/SvEvTac * 129X1/SvJ	MGI:3521928

Allelic Composition	Top2b^tm2.1Jcw/Top2b^tm2.1Jcw
Genetic Background	involves: 129S4/SvJae * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Top2b^tm2.1Jcw mutation (0 available); any Top2b mutation (91 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:94879 )

• died of respiratory failure shortly after birth

growth/size/body

decreased body size ( J:94879 )

respiratory system

respiratory failure ( J:94879 )

• died of respiratory failure

skeleton

abnormal spine curvature ( J:94879 )

• abnormal curvature of the vertebral column

nervous system

impaired neuronal migration ( J:94879 )

• late born neurons failed to migrate to the superficial layers of the neocortex

abnormal telencephalon development ( J:94879 )

• absent boundary between the intermediate zone and cortical plate

disorganized cortical plate ( J:94879 )

absent subplate ( J:94879 )

decreased brain size ( J:94879 )

• smaller brain at E16.5 and E18.5 but not at E14.5

abnormal stratification in cerebral cortex ( J:94879 )

• abnormal lamination of the neocortex

small olfactory bulb ( J:94879 )

• barely identifiable at E16.5 and remains poorly developed at E18.5

abnormal embryonic/fetal subventricular zone morphology ( J:94879 )

• thicker ventricular zone

cellular

impaired neuronal migration ( J:94879 )

• late born neurons failed to migrate to the superficial layers of the neocortex

Allelic Composition	Top2b^tm2Jcw/Top2b^tm2.1Jcw Foxg1^tm1(cre)Skm/Foxg1⁺
Genetic Background	involves: 129S4/SvJae * 129S6/SvEvTac * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1^tm1(cre)Skm mutation (2 available); any Foxg1 mutation (29 available)
Top2b^tm2.1Jcw mutation (0 available); any Top2b mutation (91 available)
Top2b^tm2Jcw mutation (1 available); any Top2b mutation (91 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:94879 )

• died of respiratory failure within 30 min after birth, however decreased body size was not observed as in homozygous Top2b mutant mice

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:94879 )

• lack the vigor of wild-type newborns, however show some body movements upon tactile stimulation

respiratory system

atelectasis ( J:94879 )

respiratory failure ( J:94879 )

• collapsed lung alveoli in dead pups suggests respiratory failure

nervous system

abnormal hippocampus morphology ( J:94879 )

abnormal hippocampus granule cell layer ( J:94879 )

• ill-defined granule cell layer in the hippocampus

abnormal hippocampus pyramidal cell layer ( J:94879 )

• ill-defined pyramidal cell layer in the hippocampus

abnormal cerebral cortex morphology ( J:94879 )

• thinner cortex

small olfactory bulb ( J:94879 )

• less developed olfactory bulb

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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