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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tph2Arg447
Arginine 447
MGI:3521924
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tph2Arg447/Tph2Arg447 BALB/cJ MGI:3525354
hm2
 		Tph2Arg447/Tph2Arg447 DBA/2J MGI:3525355


Genotype
MGI:3525354
hm1
Allelic
Composition		 Tph2Arg447/Tph2Arg447
Genetic
Background		 BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tph2Arg447 mutation (0 available); any Tph2 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal serotonin level ( J:94745 )
• ~40% decrease in serotonin levels in the frontal cortex and striatum and ~50% and ~70% reduction in the serotonin precursor 5-hydroxytryptophan (5-HTP) synthesis in the frontal cortex and striatum, respectively, after treatment with m-hydroxybenxylhydrazine, compared to mice in a 129X1/SvJ background that are homozygous for Tph2Pro447 and have a proline rather than an arginine at amino acid residue 447 of Tph2




Genotype
MGI:3525355
hm2
Allelic
Composition		 Tph2Arg447/Tph2Arg447
Genetic
Background		 DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tph2Arg447 mutation (0 available); any Tph2 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal serotonin level ( J:94745 )
• ~45% decrease in 5-HTP synthesis in the striatum after treatment with m-hydroxybenxylhydrazine, compared to mice in a C57BL/6J background that are homozygous for Tph2Pro447 and have a proline rather than an arginine at amino acid residue 447 of Tph2




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory