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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tph2Pro447
Proline 447
MGI:3521925
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tph2Pro447/Tph2Pro447 129X1/SvJ MGI:3525357
hm2
 		Tph2Pro447/Tph2Pro447 C57BL/6J MGI:3525358


Genotype
MGI:3525357
hm1
Allelic
Composition		 Tph2Pro447/Tph2Pro447
Genetic
Background		 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tph2Pro447 mutation (0 available); any Tph2 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal serotonin level ( J:94745 )
• increased serotonin levels and increased synthesis of the serotonin precursor 5-hydroxytryptophan (5-HTP) after treatment with m-hydroxybenxylhydrazine in the frontal cortex and striatum, compared to mice in a BALB/cJ background that are homozygous for TphArg447 and have an arginine rather than a proline at amino acid residue 447 of Tph2




Genotype
MGI:3525358
hm2
Allelic
Composition		 Tph2Pro447/Tph2Pro447
Genetic
Background		 C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tph2Pro447 mutation (0 available); any Tph2 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal serotonin level ( J:94745 )
• increase in 5-HTP synthesis in the striatum after treatment with m-hydroxybenxylhydrazine, compared to mice in a DBA/2J background that are homozygous for TphArg447 and have an arginine rather than a proline at amino acid residue 447 of Tph2




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory