Phenotypes associated with this allele

• Allele Symbol: Mmp13^tm1.1Werb
• Allele Name: targeted mutation 1.1, Zena Werb
• Allele ID: MGI:3521938
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mmp13^tm1.1Werb/Mmp13^tm1.1Werb	involves: 129S2/SvPas	MGI:3522358
cx2	Mmp13^tm1.1Werb/Mmp13^tm1.1Werb Mmp9^tm1Tvu/Mmp9^tm1Tvu	involves: 129S2/SvPas * 129S6/SvEvTac	MGI:3522359

Genotype
MGI:3522358

hm1

• Allelic Composition: Mmp13^tm1.1Werb/Mmp13^tm1.1Werb
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

increased width of hypertrophic chondrocyte zone ( J:94460 )

• the hypertrophic zone is expanded in the tibia and metatarsals, at E17 and 1 week after birth, respectively, however by 12 weeks of age the size of the hypertrophic zone is similar to wild-type

• chondrocytes proliferate and differentiate normally but accumulate in the most terminally differentiated hypertrophic state

• establishment of the primary ossification centers is normal

abnormal trabecular bone morphology ( J:94460 )

• the amount of trabecular bone is increased in the tibia and metatarsals by 3 weeks or 1 week of age, respectively, however by 1 year of age the amount of trabecular bone was similar to wild-type

• the organization of the trabecular bone is also irregular

Genotype
MGI:3522359

cx2

• Allelic Composition: Mmp13^tm1.1Werb/Mmp13^tm1.1Werb; Mmp9^tm1Tvu/Mmp9^tm1Tvu
• Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

growth/size/body

decreased body size ( J:94460 )

skeleton

abnormal long bone epiphyseal ossification zone morphology ( J:94460 )

• the front of ossification is similar to that seen in Mmp9 single homozygotes

abnormal long bone hypertrophic chondrocyte zone ( J:94460 )

• the normal columnar architecture is lost

increased width of hypertrophic chondrocyte zone ( J:94460 )

• seen in the long bones, more severe than in either single homozygote

abnormal bone marrow cavity morphology ( J:94460 )

• development of the bone marrow cavity is delayed

abnormal trabecular bone morphology ( J:94460 )

• decreased trabecular bone formation and abnormal growth plate development result in dramatically shortened skeletal elements

delayed bone ossification ( J:94460 )

• development of the secondary site of ossification is delayed