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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hes3tm1Kag
targeted mutation 1, Ryoichiro Kageyama
MGI:3521989
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hes3tm1Kag/Hes3tm1Kag involves: C57BL/6 * CBA * ICR MGI:3526241
cn2
 		Hes1tm1Kag/Hes1tm1Kag
Hes3tm1Kag/Hes3tm1Kag
Hes5tm1Fgu/Hes5tm1Fgu
Tg(Nes-cre/ERT2)5-1Imayo/0 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:3808127
cn3
 		Emx1tm1(cre)Ito/Emx1+
Hes1tm1Kag/Hes1tm1Kag
Hes3tm1Kag/Hes3tm1Kag
Hes5tm1Fgu/Hes5tm1Fgu 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:3808125
cx4
 		Hes1tm1Fgu/Hes1tm1Fgu
Hes3tm1Kag/Hes3tm1Kag
Hes5tm1Fgu/Hes5tm1Fgu 		involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:3526895
cx5
 		Hes1tm1Fgu/Hes1tm1Fgu
Hes3tm1Kag/Hes3tm1Kag 		involves: C57BL/6 * CBA * ICR MGI:3526242


Genotype
MGI:3526241
hm1
Allelic
Composition		 Hes3tm1Kag/Hes3tm1Kag
Genetic
Background		 involves: C57BL/6 * CBA * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hes3tm1Kag mutation (2 available); any Hes3 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:71074 )
• mutants are fertile with no obvious defects




Genotype
MGI:3808127
cn2
Allelic
Composition		 Hes1tm1Kag/Hes1tm1Kag
Hes3tm1Kag/Hes3tm1Kag
Hes5tm1Fgu/Hes5tm1Fgu
Tg(Nes-cre/ERT2)5-1Imayo/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hes1tm1Kag mutation (2 available); any Hes1 mutation (23 available)
Hes3tm1Kag mutation (2 available); any Hes3 mutation (18 available)
Hes5tm1Fgu mutation (1 available); any Hes5 mutation (16 available)
Tg(Nes-cre/ERT2)5-1Imayo mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:139170 )
N
• mice exhibit no change in Cajal-Retzius cell number




Genotype
MGI:3808125
cn3
Allelic
Composition		 Emx1tm1(cre)Ito/Emx1+
Hes1tm1Kag/Hes1tm1Kag
Hes3tm1Kag/Hes3tm1Kag
Hes5tm1Fgu/Hes5tm1Fgu
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Ito mutation (1 available); any Emx1 mutation (34 available)
Hes1tm1Kag mutation (2 available); any Hes1 mutation (23 available)
Hes3tm1Kag mutation (2 available); any Hes3 mutation (18 available)
Hes5tm1Fgu mutation (1 available); any Hes5 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron differentiation ( J:139170 )
• mice exhibit accelerated differentiation of neurons compared to in wild-type mice, including Cajal-Retzius cells in the dorsal telencephalon
abnormal embryonic neuroepithelium morphology ( J:139170 )
• unlike in wild-type mice, at E11.5 and E12.5 dorsal midline cells do not flatten and remain pseudostratified
abnormal brain morphology ( J:139170 )
• mice exhibit mild abnormalities in the cortical hem and cortical neuroepithelium
increased Cajal-Retzius cell number ( J:139170 )
• at E11.5 and E12.5, the number of Cajal-Retzius cells in the marginal zone of the piriform cortex is increased compared to in wild-type mice

embryo
abnormal embryonic neuroepithelium morphology ( J:139170 )
• unlike in wild-type mice, at E11.5 and E12.5 dorsal midline cells do not flatten and remain pseudostratified

cellular
abnormal neuron differentiation ( J:139170 )
• mice exhibit accelerated differentiation of neurons compared to in wild-type mice, including Cajal-Retzius cells in the dorsal telencephalon




Genotype
MGI:3526895
cx4
Allelic
Composition		 Hes1tm1Fgu/Hes1tm1Fgu
Hes3tm1Kag/Hes3tm1Kag
Hes5tm1Fgu/Hes5tm1Fgu
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hes1tm1Fgu mutation (1 available); any Hes1 mutation (23 available)
Hes3tm1Kag mutation (2 available); any Hes3 mutation (18 available)
Hes5tm1Fgu mutation (1 available); any Hes5 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
premature neuronal precursor differentiation ( J:94391 )
• at E8.5 many differentiated neurons have already formed unlike in Hes1, Hes5 double mutants where premature differentiation is not seen until E9.5
• at E9.5 almost all cells are neurons in the ventral spinal cord and at E10.0 virtually all radial glial cells have differentiated

cellular
premature neuronal precursor differentiation ( J:94391 )
• at E8.5 many differentiated neurons have already formed unlike in Hes1, Hes5 double mutants where premature differentiation is not seen until E9.5
• at E9.5 almost all cells are neurons in the ventral spinal cord and at E10.0 virtually all radial glial cells have differentiated




Genotype
MGI:3526242
cx5
Allelic
Composition		 Hes1tm1Fgu/Hes1tm1Fgu
Hes3tm1Kag/Hes3tm1Kag
Genetic
Background		 involves: C57BL/6 * CBA * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hes1tm1Fgu mutation (1 available); any Hes1 mutation (23 available)
Hes3tm1Kag mutation (2 available); any Hes3 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:71074 )
• most homozygous double mutants survive to E10.5 but die by E15.5

growth/size/body
embryonic growth retardation ( J:71074 )
• at E10.5 embryos show signs of growth retardation

nervous system
premature neuronal precursor differentiation ( J:71074 )
• at E10.5 more neurons are generated prematurely however many neuronal precursors remain
abnormal neural tube morphology ( J:71074 )
• all double homozygotes had some type of neural tube defect
abnormal midbrain-hindbrain boundary morphology ( J:71074 )
• at E10.5 the isthmic organizer is prematurely lost as a result of premature differentiation of neuronal precursors
abnormal midbrain morphology ( J:71074 )
• the oculomotor and trochlear motor nuclei are absent at E10.5 and E12.5
abnormal oculomotor nucleus morphology ( J:71074 )
• the oculomotor nuclei are absent at E10.5 and E12.5
abnormal locus ceruleus morphology ( J:71074 )
• the locus ceruleus is absent at E10.5
exencephaly ( J:71074 )
• some embryos had exencephaly of the whole brain while in others the defect was confined to the midbrain-hindbrain region
abnormal dopaminergic neuron morphology ( J:71074 )
• dopaminergic neurons are absent at E11.5
absent oculomotor nerve ( J:71074 )
• at E12.5 the oculomoter nerve is absent
absent trochlear nerve ( J:71074 )
• at E12.5 the trochlear nerve is absent

embryo
embryonic growth retardation ( J:71074 )
• at E10.5 embryos show signs of growth retardation
abnormal neural tube morphology ( J:71074 )
• all double homozygotes had some type of neural tube defect

cellular
premature neuronal precursor differentiation ( J:71074 )
• at E10.5 more neurons are generated prematurely however many neuronal precursors remain




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory