Phenotypes associated with this allele

• Allele Symbol: Tnfrsf10b^tm1Wnt
• Allele Name: targeted mutation 1, Astar Winoto
• Allele ID: MGI:3522001
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnfrsf10b^tm1Wnt/Tnfrsf10b^tm1Wnt	involves: 129S6/SvEvTac * C57BL/6	MGI:3525160

Genotype
MGI:3525160

hm1

• Allelic Composition: Tnfrsf10b^tm1Wnt/Tnfrsf10b^tm1Wnt
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:94681 )

• after encephalomyocarditis virus infection, homozygotes had a slightly enhanced survival rate than controls but not when a 10-fold higher viral dose was used

immune system

increased NK cell number ( J:94681 )

• observed a slight increase in CD69+ natural killer cells in MCMV-infected homozygotes indicating that NK cells were slightly more activated, however lytic activity of NK cells was normal

increased circulating interleukin-12b level ( J:94681 )

• 10-fold increase in serum levels of the IL-12 p40 subunit 24 hours after MCMV infection compared to controls

abnormal interferon level ( J:94681 )

• elevated levels of interferon-alpha and interferon-beta in spleen of MCMV-infected homozygotes compared to wild-type

increased circulating interferon-gamma level ( J:94681 )

• serum levels of interferon-gamma at 36 hours postinfection with MCMV were greatly elevated compared to wild-type

increased interleukin-12 secretion ( J:94681 )

• spleen derived dendritic cells of MCMV-infected mutants produced 8-fold more IL-12 than infected wild-type

• bone marrow derived dendritic cells stimulated with E.coli LPS had higher levels of IL-12 than controls

• peritoneal macrophages stimulated with E.coli or Salmonella LPS, lipoteichoic acid, or poly (I:C) had higher levels of IL-12 than controls

increased tumor necrosis factor secretion ( J:94681 )

• peritoneal macrophages stimulated with E.coli or Salmonella LPS had higher levels of TNF-alpha than controls

abnormal innate immunity ( J:94681 )

• enhanced innate immune responses to encephalomyocarditis virus and murine cytomegalovirus (MCMV) infection but not to Salmonella typhimurium or Listeria monocytogenes infection

decreased susceptibility to Herpesvirales infection ( J:94681 )

• 3 days after murine cytomegalovirus infection, viral titers in the spleen, but not the liver or lung, were decreased by 40-fold compared to wild-type, indicating enhanced clearance of MCMV

decreased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:94681 )

• after encephalomyocarditis virus infection, homozygotes had a slightly enhanced survival rate than controls but not when a 10-fold higher viral dose was used

hematopoietic system

increased NK cell number ( J:94681 )

• observed a slight increase in CD69+ natural killer cells in MCMV-infected homozygotes indicating that NK cells were slightly more activated, however lytic activity of NK cells was normal

homeostasis/metabolism

increased circulating interleukin-12b level ( J:94681 )

• 10-fold increase in serum levels of the IL-12 p40 subunit 24 hours after MCMV infection compared to controls

abnormal interferon level ( J:94681 )

• elevated levels of interferon-alpha and interferon-beta in spleen of MCMV-infected homozygotes compared to wild-type

increased circulating interferon-gamma level ( J:94681 )

• serum levels of interferon-gamma at 36 hours postinfection with MCMV were greatly elevated compared to wild-type