Phenotypes associated with this allele

• Allele Symbol: Clic5^nmf318
• Allele Name: neuroscience mutagenesis facility, 318
• Allele ID: MGI:3522004
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Clic5^nmf318/Clic5^nmf318	C57BL/6J-Clic5^nmf318/J	MGI:3522008

Genotype
MGI:3522008

hm1

• Allelic Composition: Clic5^nmf318/Clic5^nmf318
• Genetic Background: C57BL/6J-Clic5^nmf318/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

absent startle reflex ( J:82238 )

• mice tested at 4-5 weeks of age exhibited no acoustic startle response

head tossing ( J:82238 )

circling ( J:82238 )

nervous system

abnormal cochlear hair cell stereociliary bundle morphology ( J:238912 )

• scanning electron microscopy of mutant cochleae at 30 days of age revealed hair cell bundle abnormalities

hearing/vestibular/ear

abnormal cochlear hair cell stereociliary bundle morphology ( J:238912 )

• scanning electron microscopy of mutant cochleae at 30 days of age revealed hair cell bundle abnormalities

organ of Corti degeneration ( J:238912 )

• cochlear cross-sections at 6 weeks of age showed degeneration of the organ of Corti

increased or absent threshold for auditory brainstem response ( J:82238 , J:238912 )

• four to five week-old mice were found to have no acoustic brainstem response at any frequency or intensity tested (click, 8, 16 or 32 Hz at 30 - 90 db) (J:82238)

• ABR analysis of 6 mutant mice tested at 32 days of age showed 35-50 dB threshold elevations compared with controls, and no ABR was detected in 9 mutants tested at 70 days of age, even when subjected to the maximum 100 dB stimulus (J:238912)

deafness ( J:82238 )