All Phenotypes Nt5e<tm1Lft> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nt5e^tm1Lft/Nt5e^tm1Lft	B6.129S1-Nt5e^tm1Lft/J	MGI:6241531
hm2	Nt5e^tm1Lft/Nt5e^tm1Lft	involves: 129S1/Sv * C57BL/6	MGI:3524958
cx3	Abcc6^tm1Jfk/Abcc6^tm1Jfk Nt5e^tm1Lft/Nt5e^tm1Lft	B6.Cg-Abcc6^tm1Jfk Nt5e^tm1Lft	MGI:6241525

Allelic Composition	Nt5e^tm1Lft/Nt5e^tm1Lft
Genetic Background	B6.129S1-Nt5e^tm1Lft/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nt5e^tm1Lft mutation (3 available); any Nt5e mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal snout skin morphology ( J:252837 )

calcified skin ( J:252837 )

• mild calcification of the fibrous capsule surrounding the muzzle vibrissae is observed by one year of age

growth/size/body

abnormal snout skin morphology ( J:252837 )

homeostasis/metabolism

calcinosis ( J:252837 )

craniofacial

abnormal snout skin morphology ( J:252837 )

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

lethargy ( J:94697 )

• under hypoxic conditions mutants are more lethargic compared to wild-type littermates

increased aggression towards humans ( J:94697 )

• under hypoxic conditions mutants are less compliant compared to wild-type littermates

cardiovascular system

abnormal response to cardiac infarction ( J:131444 )

• ischemic preconditioning fails to attenuate infarct size as in wild-type mice

• however, treatment of mice with adenosine or 5' nucleotidase infusion partially-restores cardioprotection offered by ischemic preconditioning

increased myocardial infarct size ( J:131444 )

• mice exhibit increased infarct size after 60 minutes of ischemia compared to in similarly-treated wild-type mice

increased vascular permeability ( J:94697 )

• under hypoxic conditions increased vascular leakage is seen

• under normoxic conditions increased vascular permeability is seen in the lung and colon

homeostasis/metabolism

abnormal response to cardiac infarction ( J:131444 )

• ischemic preconditioning fails to attenuate infarct size as in wild-type mice

• however, treatment of mice with adenosine or 5' nucleotidase infusion partially-restores cardioprotection offered by ischemic preconditioning

increased myocardial infarct size ( J:131444 )

• mice exhibit increased infarct size after 60 minutes of ischemia compared to in similarly-treated wild-type mice

edema ( J:94697 )

• under hypoxic conditions increased edema is seen in all organs except the brain

abnormal response/metabolism to endogenous compounds ( J:131444 )

• mice exhibit an attenuated bradycardia response to AMP

Allelic Composition	Abcc6^tm1Jfk/Abcc6^tm1Jfk Nt5e^tm1Lft/Nt5e^tm1Lft
Genetic Background	B6.Cg-Abcc6^tm1Jfk Nt5e^tm1Lft

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc6^tm1Jfk mutation (1 available); any Abcc6 mutation (76 available)
Nt5e^tm1Lft mutation (3 available); any Nt5e mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

calcinosis ( J:252837 )

integument

abnormal snout skin morphology ( J:252837 )

calcified skin ( J:252837 )

• mild calcification of the fibrous capsule surrounding the muzzle vibrissae is observed by one year of age

growth/size/body

abnormal snout skin morphology ( J:252837 )

craniofacial

abnormal snout skin morphology ( J:252837 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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