Phenotypes associated with this allele

• Allele Symbol: Cd209b^tm1Anjm
• Allele Name: targeted mutation 1, Andrew NJ McKenzie
• Allele ID: MGI:3522018
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd209b^tm1Anjm/Cd209b^tm1Anjm	B6.129P2-Cd209b^tm1Anjm	MGI:3525070
hm2	Cd209b^tm1Anjm/Cd209b^tm1Anjm	C.129P2-Cd209b^tm1Anjm	MGI:6431840
hm3	Cd209b^tm1Anjm/Cd209b^tm1Anjm	involves: 129P2/OlaHsd * BALB/c	MGI:6431793
hm4	Cd209b^tm1Anjm/Cd209b^tm1Anjm	involves: 129P2/OlaHsd * C57BL/6	MGI:3525067

Genotype
MGI:3525070

hm1

• Allelic Composition: Cd209b^tm1Anjm/Cd209b^tm1Anjm
• Genetic Background: B6.129P2-Cd209b^tm1Anjm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

decreased susceptibility to induced colitis ( J:159646 )

• mice exhibit reduced susceptibility to dextran sodium sulfate (DSS)-induced colitis, showing less severe colitis, less shortening of the colon, less inflammation and colon damage, and decreased proinflammatory cytokine levels

immune system

decreased susceptibility to induced colitis ( J:159646 )

• mice exhibit reduced susceptibility to dextran sodium sulfate (DSS)-induced colitis, showing less severe colitis, less shortening of the colon, less inflammation and colon damage, and decreased proinflammatory cytokine levels

decreased interleukin-1 beta secretion ( J:159646 )

• peritoneal macrophages show reduced LPS-induced lL-1beta production

decreased interleukin-18 secretion ( J:159646 )

• peritoneal macrophages show reduced LPS-induced IL-18 production

decreased susceptibility to endotoxin shock ( J:159646 )

• mice show reduced susceptibility to LPS-induced shock, showing higher survival, reduced clinical signs of shock and reduced proinflammatory levels

increased susceptibility to bacterial infection induced morbidity/mortality ( J:94698 )

• only 40% of homozygous mutants survive 48 hours after intraperitoneal infection with 10³ S. pneumoniae compared to 100% of wild-type and 0% survive after infection with 10⁴ S. pneumoniae compared to 90% in wild-type

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:94698 )

• only 40% of homozygous mutants survive 48 hours after intraperitoneal infection with 10³ S. pneumoniae compared to 100% of wild-type and 0% survive after infection with 10⁴ S. pneumoniae compared to 90% in wild-type

Genotype
MGI:6431840

hm2

• Allelic Composition: Cd209b^tm1Anjm/Cd209b^tm1Anjm
• Genetic Background: C.129P2-Cd209b^tm1Anjm

immune system

immune system phenotype ( J:143766 )

N • mice infected with Schistosoma mansoni show a normal acute and chronic response to infection, showing comparable size and eosinophil content of granulomas surrounding eggs in the liver as in wild-type mice, with no differences in plasma levels of aspartate transaminase and normal downmodulation of inflammatory responses in chronic stages of infection

N • mice injected intravenously with schistosome eggs evoke granulomatous inflammation around eggs trapped in the lungs similarly as wild-type mice with no differences in pulmonary egg granulomas

Genotype
MGI:6431793

hm3

• Allelic Composition: Cd209b^tm1Anjm/Cd209b^tm1Anjm
• Genetic Background: involves: 129P2/OlaHsd * BALB/c

immune system

immune system phenotype ( J:209808 )

N • mice inoculated with Candida albicans show vaginal fungal burden and polymorphonuclear neutrophil migration to the vagina that are similar to that seen in wild-type mice

Genotype
MGI:3525067

hm4

• Allelic Composition: Cd209b^tm1Anjm/Cd209b^tm1Anjm
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

cellular

impaired macrophage phagocytosis ( J:94698 )

• fewer than half as many macrophages phagocytosed S. pneumoniae at 37C compared with controls, with the reduction in phagocytosis being proportional to the reduction in surface binding

• marginal zone macrophages of the spleen failed to phagocytose the polysaccharide dextran

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:94698 )

• more rapid mortality after S. pneumoniae infection, with only 20% of homozygotes surviving at 48 hours compared to 90% of wild-type

immune system

abnormal macrophage physiology ( J:94698 )

• peritoneal macrophages were impaired (3-fold reduction) in ability to bind S. pneumoniae at 4C after infection

• marginal zone macrophages in the spleen were impaired in trapping S.pneumoniae in the marginal zone and clearing the bacteria from the circulation

impaired macrophage phagocytosis ( J:94698 )

• fewer than half as many macrophages phagocytosed S. pneumoniae at 37C compared with controls, with the reduction in phagocytosis being proportional to the reduction in surface binding

• marginal zone macrophages of the spleen failed to phagocytose the polysaccharide dextran

increased susceptibility to bacterial infection ( J:94698 )

• less than 18% of homozygotes survived infection with S. pneumoniae compared with more than 60% of wild-type and exhibited persistent septicemia after infection compared with controls

increased susceptibility to bacterial infection induced morbidity/mortality ( J:94698 )

• more rapid mortality after S. pneumoniae infection, with only 20% of homozygotes surviving at 48 hours compared to 90% of wild-type

hematopoietic system

abnormal macrophage physiology ( J:94698 )

• peritoneal macrophages were impaired (3-fold reduction) in ability to bind S. pneumoniae at 4C after infection

• marginal zone macrophages in the spleen were impaired in trapping S.pneumoniae in the marginal zone and clearing the bacteria from the circulation

impaired macrophage phagocytosis ( J:94698 )

• fewer than half as many macrophages phagocytosed S. pneumoniae at 37C compared with controls, with the reduction in phagocytosis being proportional to the reduction in surface binding

• marginal zone macrophages of the spleen failed to phagocytose the polysaccharide dextran