Phenotypes associated with this allele

• Allele Symbol: Tg(Tyrp1-TAg)3434Bee
• Allele Name: transgene insertion 3434, Friedrich Beermann
• Allele ID: MGI:3522144
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Fgf2^tm1Bee/Fgf2^tm1Bee Tg(Tyrp1-TAg)3434Bee/?	involves: 129P2/OlaHsd * BALB/c * C57BL/6	MGI:3763732
cx2	Fgf2^tm1Bee/Fgf2^+ Tg(Tyrp1-TAg)3434Bee/?	involves: 129P2/OlaHsd * BALB/c * C57BL/6	MGI:3763733
tg3	Tg(Tyrp1-TAg)3434Bee/?	involves: BALB/c * C57BL/6J	MGI:3763734

Genotype
MGI:3763732

cx1

• Allelic Composition: Fgf2^tm1Bee/Fgf2^tm1Bee; Tg(Tyrp1-TAg)3434Bee/?
• Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

increased eye tumor incidence ( J:75629 )

• eye tumors develop at 2 to 3 months of age with pigmented cells observed in the inguinal lymph nodes and, in some mice, the spleen

• in 1-day old mice, tumors are present in the anterior part of the retinal pigmented epithelium and the optic nerve

• in 14-day old mice, tumors are advanced further and the posterior eye cavity is filled with tumor cells

• tumor cells are poorly pigmented or nonpigmented

• however, islet of pigmented cells can be observed in the optic nerve

mortality/aging

decreased tumor-free survival time ( J:75629 )

• mice die at 11.7 weeks of age likely due to proliferation of tumor cells in the brain and near the optic chiasm

neoplasm

increased eye tumor incidence ( J:75629 )

• eye tumors develop at 2 to 3 months of age with pigmented cells observed in the inguinal lymph nodes and, in some mice, the spleen

• in 1-day old mice, tumors are present in the anterior part of the retinal pigmented epithelium and the optic nerve

• in 14-day old mice, tumors are advanced further and the posterior eye cavity is filled with tumor cells

• tumor cells are poorly pigmented or nonpigmented

• however, islet of pigmented cells can be observed in the optic nerve

Genotype
MGI:3763733

cx2

• Allelic Composition: Fgf2^tm1Bee/Fgf2⁺; Tg(Tyrp1-TAg)3434Bee/?
• Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

mortality/aging

decreased tumor-free survival time ( J:75629 )

• mice die at 11.5 weeks of age likely due to proliferation of tumor cells in the brain and near the optic chiasm

Genotype
MGI:3763734

tg3

• Allelic Composition: Tg(Tyrp1-TAg)3434Bee/?
• Genetic Background: involves: BALB/c * C57BL/6J

vision/eye

increased eye tumor incidence ( J:75629 )

• eye tumors develop at 2 to 3 months of age with pigmented cells observed in the inguinal lymph nodes and, in some mice, the spleen

• in 1-day old mice, tumors are present in the anterior part of the retinal pigmented epithelium and the optic nerve

• in 14-day old mice, tumors are advanced further and the posterior eye cavity is filled with tumor cells

• tumor cells are poorly pigmented or nonpigmented

• however, islet of pigmented cells can be observed in the optic nerve

mortality/aging

decreased tumor-free survival time ( J:75629 )

• mice die at 11.6 weeks of age likely due to proliferation of tumor cells in the brain and near the optic chiasm

neoplasm

increased eye tumor incidence ( J:75629 )

• eye tumors develop at 2 to 3 months of age with pigmented cells observed in the inguinal lymph nodes and, in some mice, the spleen

• in 1-day old mice, tumors are present in the anterior part of the retinal pigmented epithelium and the optic nerve

• in 14-day old mice, tumors are advanced further and the posterior eye cavity is filled with tumor cells

• tumor cells are poorly pigmented or nonpigmented

• however, islet of pigmented cells can be observed in the optic nerve

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
retinal cancer		DOID:4645		J:75629