All Phenotypes Notch2<tm1Rko> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Notch2^tm1Rko
targeted mutation 1, Raphael Kopan
MGI:3522155

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Notch1^tm2Rko/Notch1^tm2Rko Notch2^tm1Rko/Notch2^tm1Rko Notch3^{Gt(PST033)Byg}/Notch3^{Gt(PST033)Byg} Tg(Msx2-cre)5Rem/0	involves: 129P2/OlaHsd * 129X1/SvJ	MGI:3525189
cn2	Notch1^tm2Rko/Notch1^tm2Rko Notch2^tm1Rko/Notch2^tm1Rko Notch3^{Gt(PST033)Byg}/Notch3^{Gt(PST033)Byg} Tg(Mx1-cre)1Cgn/0	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA	MGI:5009039
cn3	Notch1^tm2Rko/Notch1^tm2Rko Notch2^tm1Rko/Notch2^tm1Rko Notch3^{Gt(PST033)Byg}/Notch3⁺ Tg(Mx1-cre)1Cgn/0	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA	MGI:5009045
cn4	Notch1^tm2Rko/Notch1^tm2Rko Notch2^tm1Rko/Notch2^tm1Rko Tg(Msx2-cre)5Rem/0	involves: 129X1/SvJ * C57BL/6 * CBA	MGI:3525181
cn5	Notch2^tm1Rko/Notch2^tm1Rko Tg(Msx2-cre)5Rem/0	Not Specified	MGI:3525174

Allelic Composition	Notch1^tm2Rko/Notch1^tm2Rko Notch2^tm1Rko/Notch2^tm1Rko Notch3^{Gt(PST033)Byg}/Notch3^{Gt(PST033)Byg} Tg(Msx2-cre)5Rem/0
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1^tm2Rko mutation (3 available); any Notch1 mutation (117 available)
Notch2^tm1Rko mutation (0 available); any Notch2 mutation (99 available)
Notch3^{Gt(PST033)Byg} mutation (0 available); any Notch3 mutation (94 available)
Tg(Msx2-cre)5Rem mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

absent sebaceous gland ( J:94517 )

• loss of sebaceous glands in embryo-deleted follicles

integument

absent sebaceous gland ( J:94517 )

• loss of sebaceous glands in embryo-deleted follicles

thick epidermis ( J:94517 )

• had frequent acanthotic and perakeratotic scales

scaly skin ( J:94517 )

• had frequent perakeratotic scales

Allelic Composition	Notch1^tm2Rko/Notch1^tm2Rko Notch2^tm1Rko/Notch2^tm1Rko Notch3^{Gt(PST033)Byg}/Notch3^{Gt(PST033)Byg} Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal definitive hematopoiesis ( J:172442 )

• increase in the granulocyte/monocyte progenitors cell population

extramedullary hematopoiesis ( J:172442 )

increased hematopoietic cell number ( J:172442 )

• increase in the granulocyte/monocyte progenitors cell population

abnormal spleen morphology ( J:172442 )

• massive invasion of myeloid cells

enlarged spleen ( J:172442 )

increased spleen red pulp amount ( J:172442 )

neoplasm

increased leukemia incidence ( J:172442 )

• similarity to chronic myelomonocytic leukemia

immune system

abnormal spleen morphology ( J:172442 )

• massive invasion of myeloid cells

enlarged spleen ( J:172442 )

increased spleen red pulp amount ( J:172442 )

growth/size/body

enlarged spleen ( J:172442 )

Allelic Composition	Notch1^tm2Rko/Notch1^tm2Rko Notch2^tm1Rko/Notch2^tm1Rko Notch3^{Gt(PST033)Byg}/Notch3⁺ Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

extramedullary hematopoiesis ( J:172442 )

increased hematopoietic cell number ( J:172442 )

• myeloproliferative disease

abnormal spleen morphology ( J:172442 )

• massive invasion of myeloid cells

enlarged spleen ( J:172442 )

increased spleen red pulp amount ( J:172442 )

immune system

abnormal spleen morphology ( J:172442 )

• massive invasion of myeloid cells

enlarged spleen ( J:172442 )

increased spleen red pulp amount ( J:172442 )

growth/size/body

enlarged spleen ( J:172442 )

Allelic Composition	Notch1^tm2Rko/Notch1^tm2Rko Notch2^tm1Rko/Notch2^tm1Rko Tg(Msx2-cre)5Rem/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:94517 )

• die around P25

endocrine/exocrine glands

absent sebaceous gland ( J:94517 )

• loss of sebaceous glands in embryo-deleted follicles

integument

absent sebaceous gland ( J:94517 )

• loss of sebaceous glands in embryo-deleted follicles

progressive hair loss ( J:94517 )

• regions of bald skin (where Cre was expressed in E9.5 developing follicles) alternating with hair (where Cre was expressed at P1 in follicle cells), however this hair was progressively lost as mice age

absent hair follicle inner root sheath ( J:94517 )

• embryo-deleted follicles contain a melanin-producing core with large, loosely packed cells replacing the inner root sheath

hair follicle degeneration ( J:94517 )

• by P25, P1-deleted follicles are degenerating instead of being in telogen

epidermal hyperplasia ( J:94517 )

scaly skin ( J:94517 )

• regions of scaly skin

Allelic Composition	Notch2^tm1Rko/Notch2^tm1Rko Tg(Msx2-cre)5Rem/0
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch2^tm1Rko mutation (0 available); any Notch2 mutation (99 available)
Tg(Msx2-cre)5Rem mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:94517 )

• indistinguishable from wild-type

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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