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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Srftm1Rmn
targeted mutation 1, Narendrakumar Ramanan
MGI:3522206
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Srftm1Rmn/Srftm1Rmn
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: 129S6/SvEvTac * C57BL/6J * CBA/J MGI:5659953
cn2
 		Srftm1Rmn/Srftm1Rmn
Tg(Tagln-cre)1Jomm/0 		involves: CD-1 MGI:3522658


Genotype
MGI:5659953
cn1
Allelic
Composition		 Srftm1Rmn/Srftm1Rmn
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Srftm1Rmn mutation (1 available); any Srf mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:144862 )
• mice die at late embryonic stages

craniofacial
craniofacial phenotype ( J:144862 )
N
• tongue is present

cardiovascular system

hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:144862 )
N
• external ear is present

immune system

skeleton

hematopoietic system

endocrine/exocrine glands




Genotype
MGI:3522658
cn2
Allelic
Composition		 Srftm1Rmn/Srftm1Rmn
Tg(Tagln-cre)1Jomm/0
Genetic
Background		 involves: CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srftm1Rmn mutation (1 available); any Srf mutation (27 available)
Tg(Tagln-cre)1Jomm mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:94725 )
• no viable embryos are found after E11.5

cardiovascular system
vascular smooth muscle hypotrophy ( J:94725 )
• a 35% decrease in smooth muscle cells at the dorsal aspect of the aorta is found
abnormal myocardial fiber morphology ( J:94725 )
• the sarcomeres and Z disks are disorganized and the myofilaments are disarrayed

muscle
vascular smooth muscle hypotrophy ( J:94725 )
• a 35% decrease in smooth muscle cells at the dorsal aspect of the aorta is found
abnormal myocardial fiber morphology ( J:94725 )
• the sarcomeres and Z disks are disorganized and the myofilaments are disarrayed




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory